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Parkin antibody (C-Term)

PARK2 Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN350726
  • Target See all Parkin (PARK2) Antibodies
    Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
    Binding Specificity
    • 17
    • 17
    • 16
    • 9
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 76
    • 27
    • 26
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 102
    • 7
    • 1
    Rabbit
    Clonality
    • 103
    • 7
    Polyclonal
    Conjugate
    • 55
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    This Parkin antibody is un-conjugated
    Application
    • 98
    • 40
    • 39
    • 39
    • 21
    • 20
    • 18
    • 16
    • 9
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    Specific for Parkin.
    Immunogen
    A synthetic peptide from the c-terminal of Parkin (PARK2, Parkinson disease protein 2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and shares 95% identity with mouse sequence.
    Isotype
    IgG
    Top Product
    Discover our top product PARK2 Primary Antibody
  • Application Notes
    A concentration of 10-50 µg/ml is recommended.
    The optimal concentration should be determined by the end user.
    Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
    Alternative Name
    Parkin (PARK2 Products)
    Synonyms
    CG10523 antibody, Dmel\\CG10523 antibody, Dpark antibody, SD01679 antibody, dpk antibody, AR-JP antibody, LPRS2 antibody, PDJ antibody, PRKN antibody, Park antibody, Prkn antibody, si:ch211-123f21.1 antibody, zgc:112390 antibody, pdr-1 antibody, PARK2 antibody, parkin antibody, parkin RBR E3 ubiquitin protein ligase antibody, Parkinson disease (autosomal recessive, juvenile) 2, parkin antibody, park antibody, PRKN antibody, Prkn antibody, prkn antibody, CpipJ_CPIJ014867 antibody, Park2 antibody
    Background
    Function: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP and SEPT5. May play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Regulates cyclin E during neuronal apoptosis. May represent a tumor suppressor gene.
    Subcellular location: Cytoplasm. Nucleus. Note:  Co-localizes with SYT11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies.
    Tissue specificity: Highly expressed in the brain including the substantia nigra. Expressed in heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients. Overexpression protects dopamine neurons from kainate-mediated apoptosis. Also known as: AR JP, E3 ubiquitin protein ligase parkin, FRA6E, LPRS 2, LPRS2, PARK 2, PARK2, Parkinson disease (autosomal recessive juvenile) 2, Parkinson disease protein 2, Parkinson juvenile disease protein 2, PDJ, PRKN 2, PRKN, PRKN2, Ubiquitin E3 ligase PRKN.
    Pathways
    Autophagy, Ubiquitin Proteasome Pathway
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