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Details for Product No. ABIN350806

Ras Homolog Gene Family, Member U (RHOU) (Internal Region) antibody

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Antigen
Synonyms ARHU, CDC42L1, DJ646B12.2, WRCH1, fJ646B12.2, hG28K, Arhu, G28K, mG28K, WRCH-1, AI182090, 2310026M05Rik, arhu, hg28k, wrch1, wrch-1, cdc42l1, MGC107947, fj646b12.2
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350806
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of human Rho related GTP binding protein RhoU (CDC42 like GTPase 1, CDC42L1, Ryu GTPase) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 90% identity with rat and mouse sequence.
Isotype IgG
Specificity Appears to be specific for RhoU.
Purity IgG
Alternative Name RhoU (CDC42 like GTPase 1, CDC42L1)
Background Function: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound.
Subcellular location: Cell membrane, Lipid-anchor, Cytoplasmic side. Golgi apparatus membrane, Lipid-anchor. Cell junction › focal adhesion. Cell projection › podosome. Note: Localizes to podosomes in SRC-transformed cells.
Tissue specificity: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta. Also known as: Rho related GTP binding protein RhoU, RhoU, Ryu GTPase, CDC42-like GTPase 1, Rho GTPase-like protein ARHU, GTP-binding protein-like 1, ARHU, CDC42L1, G28K, WRCH1, Wnt-1 responsive Cdc42 homolog 1.
UniProt Q7L0Q8
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Tao, Pennica, Xu et al.: "Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1." in: Genes & development, Vol. 15, Issue 14, pp. 1796-807, 2001 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Bubb, Bovee, Buckley et al.: "Scan of human genome reveals no new Loci under ancient balancing selection." in: Genetics, Vol. 173, Issue 4, pp. 2165-77, 2006 (PubMed).

Ory, Brazier, Blangy: "Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration." in: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 99, Issue 12, pp. 701-16, 2007 (PubMed).

Alternatives for antigen "Ras Homolog Gene Family, Member U (RHOU)", type "Antibodies"
Hosts (25), (7)
Reactivities (27), (21), (15), (13)
Applications (18), (12), (10), (7), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (3), (2)
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