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SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (Internal Region) antibody

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Synonyms DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2, Prosap2, AI841104, Shank3b
Internal Region
(38), (19), (4), (2), (2), (1), (1), (1), (1)
Human, Rat (Rattus), Mouse (Murine)
(76), (61), (46), (2)
(61), (26), (1)
(4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(77), (67), (56), (41), (40), (11), (4), (4), (2), (1), (1)
Pubmed 5 references available
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Quantity 500 μg
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of human SHANK3 (SH3 and multiple ankyrin repeat domains protein 3, ProSAP2) conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for SHANK3.
Alternative Name SHANK3 (SHANK3 Antibody Abstract)
Background Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Subcellular location: Cytoplasm. Cell junction › synapse. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Note: Postsynaptic density of neuronal cells. Extends into the region subjacent to the PSD.
Tissue specificity: Widely expressed in brain. Also known as: SH3 and multiple ankyrin repeat domains protein 3, ProSAP2, Proline rich synapse associated protein 2, PSAP2.
Research Area Neurology
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Zahedi, Lewandrowski, Wiesner et al.: "Phosphoproteome of resting human platelets." in: Journal of proteome research, Vol. 7, Issue 2, pp. 526-34, 2008 (PubMed).

Durand, Betancur, Boeckers et al.: "Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders." in: Nature genetics, Vol. 39, Issue 1, pp. 25-7, 2006 (PubMed).

Soltau, Richter, Kreienkamp: "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42." in: Molecular and cellular neurosciences, Vol. 21, Issue 4, pp. 575-83, 2002 (PubMed).

Hirosawa, Nagase, Murahashi et al.: "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 8, Issue 1, pp. 1-9, 2001 (PubMed).

Dunham, Shimizu, Roe et al.: "The DNA sequence of human chromosome 22. ..." in: Nature, Vol. 402, Issue 6761, pp. 489-95, 1999 (PubMed).

Catalog No. ABIN350832
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