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Details for Product No. ABIN351008

T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1) antibody

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Synonyms AI847750, D16Ium10, D16Ium10e, TIAM1, tiam1
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (IHC)
Pubmed 8 references available
Catalog no. ABIN351008
Quantity 500 µg
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide as a part of human, mouse T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1, TIAM1) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Appears to be specific for TIAM1.
Purity IgG
Alternative Name T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1, TIAM1)
Background Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
Subunit: Interacts with BAIAP2.
Tissue specificity: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas. Also known as: TIAM-1, TIAM1.
UniProt Q13009
Application Notes IHC. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Habets, van der Kammen, Stam et al.: "Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin." in: Oncogene, Vol. 10, Issue 7, pp. 1371-6, 1995 (PubMed).

Habets, van der Kammen, Jenkins et al.: "The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16." in: Cytogenetics and cell genetics, Vol. 70, Issue 1-2, pp. 48-51, 1995 (PubMed).

Michiels, Habets, Stam et al.: "A role for Rac in Tiam1-induced membrane ruffling and invasion." in: Nature, Vol. 375, Issue 6529, pp. 338-40, 1995 (PubMed).

Hattori, Fujiyama, Taylor et al.: "The DNA sequence of human chromosome 21." in: Nature, Vol. 405, Issue 6784, pp. 311-9, 2000 (PubMed).

Worthylake, Rossman, Sondek: "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1." in: Nature, Vol. 408, Issue 6813, pp. 682-8, 2000 (PubMed).

Connolly, Rice, Feig et al.: "Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation." in: Molecular and cellular biology, Vol. 25, Issue 11, pp. 4602-14, 2005 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Cao, Yu, Banh et al.: "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 9, pp. 5864-76, 2007 (PubMed).

Alternatives for antigen "T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1)", type "Antibodies"
Hosts (22), (4), (1)
Reactivities (24), (14), (13), (12), (12), (12)
Applications (11), (10), (8), (6), (4), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (2), (1), (1), (1)