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Details for Product No. ABIN351085

Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) (Extracellular Domain) antibody

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Synonyms TRKC, gp145(trkC), AW125844, Ntrk3_tv3, TrkC, trkC, NTRK3
»Alternatives Extracellular Domain
»Alternatives Rat (Rattus), Mouse (Murine), Human, Monkey
»Alternatives Sheep
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 8 references available
Catalog no. ABIN351085
Quantity 500 µg
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the extracellular domain of rat TrkC (Trk-C, NTRK3, NT-3 growth factor receptor, GP145-TrkC) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse, human and monkey.
Isotype IgG
Specificity Appears to be specific for TrkC.
Purity IgG
Alternative Name TrkC (Trk-C, NTRK3, NT-3 growth factor receptor)
Background Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
Subcellular location: Membrane, Single-pass type I membrane protein.
Tissue specificity: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. Also known as: Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3.
UniProt Q03351
Application Notes IHC, WB (confirmed by recombinant protein). A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Merlio, Ernfors, Jaber et al.: "Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system." in: Neuroscience, Vol. 51, Issue 3, pp. 513-32, 1993 (PubMed).

McGregor, Baylin, Griffin et al.: "Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant." in: Genomics, Vol. 22, Issue 2, pp. 267-72, 1995 (PubMed).

Shelton, Sutherland, Gripp et al.: "Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 1 Pt 2, pp. 477-91, 1995 (PubMed).

Valenzuela, Maisonpierre, Glass et al.: "Alternative forms of rat TrkC with different functional capabilities." in: Neuron, Vol. 10, Issue 5, pp. 963-74, 1993 (PubMed).

Tsoulfas, Soppet, Escandon et al.: "The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells." in: Neuron, Vol. 10, Issue 5, pp. 975-90, 1993 (PubMed).

Qian, Riccio, Zhang et al.: "Identification and characterization of novel substrates of Trk receptors in developing neurons." in: Neuron, Vol. 21, Issue 5, pp. 1017-29, 1999 (PubMed).

Ultsch, Wiesmann, Simmons et al.: "Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC." in: Journal of molecular biology, Vol. 290, Issue 1, pp. 149-59, 1999 (PubMed).

Ballif, Carey, Sunyaev et al.: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).

Alternatives for antigen "Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3)", type "Antibodies"
Hosts (64), (29), (8), (7), (2)
Reactivities (87), (47), (45), (3), (2), (1), (1), (1), (1)
Applications (82), (36), (31), (23), (18), (10), (6), (5), (4), (2), (1), (1)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (11), (6), (5), (4), (4), (4), (4), (3), (2), (2), (2), (2), (1), (1)