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Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) (4th Cytoplasmic Loop) antibody

Antigen

Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1)
Synonyms ANKTM1, CT18073, TRPA, TRPA1, dANKTM1, dTRPA1, Dmel\CG5751, CG5751, Anktm1, trpa1, GLEAN_02449
Binding Site
Alternatives

4th Cytoplasmic Loop
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Application
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
2 references available
Catalog no. ABIN351101
Quantity 500 µg  (Variants)
Price 454.67 $   Plus shipping costs $45.00
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Additional Information
Application Details Publications Alternatives Variants back to top

Alternative name TRPA1 (ANKTM1)
UniProt Q6RI86
Immunogen A synthetic peptide from the 4th cytoplasmic loop of rat TRPA1 (ANKTM1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse.
Format Lyophilized
Isotype IgG
Description The structure of the protein encoded by this gene is highly related to both the protein ankyrin andtransmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. TISSUE SPECIFICITY: Expressed in inner ear. In inner ear, it is found in the distal half of stereocilia, along the length of the kinocilium and at high level in the pericuticular zone (at protein level). Specifically expressed in a subset of nociceptive neurons. Expressed in the same neurons that TRPV1. In contrast, it is not expressed in neurons expressing TRPM8. Expressed in the superior cervical ganglion. DEVELOPMENTAL STAGE: During utricle development, it is first expressed at E15 and E16 and peaks at E17. It drops at E18 but increases again at E19, possibly corresponding to a second wave of hair cells that are generated at E15. Inhibited by ruthenium red, a potent blocker of TRPV channels. Also known as: Transient receptor potential cation channel subfamily A member 1, ankyrin-like withtransmembrane domains protein 1, transformation sensitive protein p120, ANKTM1.
Specificity Appears to be specific for TRPA1.

Application Details
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Application Notes IHC, WB. Use at a concentration of 10-50 µg/ml. The optimal working concentration should be determined by the end user. Not yet tested in other applications.
Purity IgG
Storage Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Story, Peier, Reeve et al.: "ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures." in: Cell, Vol. 112, Issue 6, pp. 819-29, 2003 (PubMed).

Jordt, Bautista, Chuang et al.: "Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1." in: Nature, Vol. 427, Issue 6971, pp. 260-5, 2004 (PubMed).