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K(lysine) Acetyltransferase 2A (KAT2A) (N-Term) antibody

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Synonyms KAT2A, GCN5L2, GCN5, PCAF-b, hGCN5, 1110051E14Rik, AW212720, Gcn5, Gcn5l2, mmGCN5
(26), (17), (8), (7), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(84), (16), (6), (2)
(59), (25)
(2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(71), (42), (12), (8), (6), (4), (4), (3), (3), (1)
Pubmed 4 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human GCN5.
Isotype Ig
Specificity This antibody is specific to GCN5 (N-term).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name KAT2A / GCN5L2 (KAT2A Antibody Abstract)
Background GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. This protein has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles.Synonyms: General control of amino acid synthesis protein 5-like 2, HGCN5, Histone acetyltransferase GCN5, Histone acetyltransferase KAT2A, HsGCN5, Lysine acetyltransferase 2A, STAF97
Gene ID 2648, 9606
UniProt Q92830
Application Notes ELISA: 1/1,000. Western Blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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Background publications Sabò, Lusic, Cereseto et al.: "Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2201-12, 2008 (PubMed).

Wiper-Bergeron, Salem, Tomlinson et al.: "Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 8, pp. 2703-8, 2007 (PubMed).

Oishi, Kitagawa, Wada et al.: "An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification." in: The Journal of biological chemistry, Vol. 281, Issue 1, pp. 20-6, 2006 (PubMed).

Kikuchi, Takami, Nakayama: "GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes." in: Gene, Vol. 347, Issue 1, pp. 83-97, 2005 (PubMed).

Catalog No. ABIN356619
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