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SMT3 Suppressor of Mif Two 3 Homolog 4 (S. Cerevisiae) (SUMO4) (Met55Val-Mutant) antibody

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Synonyms IDDM5, SMT3H4, SUMO-4, dJ281H8.4
(12), (10), (9), (9), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1)
(67), (3), (3)
(63), (4)
(4), (4), (4), (4), (4), (4)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(60), (48), (36), (8), (3), (2)
Pubmed 7 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated peptide CEPRGLS(V)KQIRFRFG selected from human SUMO4. This antibody is affinity purified using peptides CEPRGLS(V)KQIRFRFG (positive selection) and CEPRGLS(M)KQIRFRFG (negative selection).
Isotype Ig
Specificity This antibody is specific to SUMO4 (V55 Mutant).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name SUMO4 / SMT3H4 (SUMO4 Antibody Abstract)
Background SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.Synonyms: SUMO-4, Small ubiquitin-like protein 4, Small ubiquitin-related modifier 4
Gene ID 387082, 9606
UniProt Q6EEV6
Application Notes ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry on paraffin sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-SMT3 Suppressor of Mif Two 3 Homolog 4 (S. Cerevisiae) (SUMO4) (Met55Val-Mutant) antibody (ABIN356787) anti-SMT3 Suppressor of Mif Two 3 Homolog 4 (S. Cerevisiae) (SUMO4) (Met55Val-Mutant) antibody
 image for anti-SMT3 Suppressor of Mif Two 3 Homolog 4 (S. Cerevisiae) (SUMO4) (Met55Val-Mutant) antibody (ABIN356787) anti-SMT3 Suppressor of Mif Two 3 Homolog 4 (S. Cerevisiae) (SUMO4) (Met55Val-Mutant) antibody (Image 2)
Background publications Guo, Li, Zhang et al.: "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. ..." in: Nature genetics, Vol. 36, Issue 8, pp. 837-41, 2004 (PubMed).

Bohren, Nadkarni, Song et al.: "A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus." in: The Journal of biological chemistry, Vol. 279, Issue 26, pp. 27233-8, 2004 (PubMed).

Yang, Sharrocks: "SUMO promotes HDAC-mediated transcriptional repression." in: Molecular cell, Vol. 13, Issue 4, pp. 611-7, 2004 (PubMed).

Ling, Sankpal, Robertson et al.: "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription." in: Nucleic acids research, Vol. 32, Issue 2, pp. 598-610, 2004 (PubMed).

Pountney, Huang, Burns et al.: "SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease." in: Experimental neurology, Vol. 184, Issue 1, pp. 436-46, 2003 (PubMed).

Bailey, OHare: "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 692-703, 2003 (PubMed).

Ohshima, Shimotohno: "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 50833-42, 2003 (PubMed).

Catalog No. ABIN356787
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