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Toll-Like Receptor 6 (TLR6) (N-Term) antibody

Details for Product No. ABIN357054, Supplier: Login to see New
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Synonyms TLR1, TLR16, CD286, TLR-6
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(37), (23), (14), (14), (11), (9), (9), (8), (7), (5), (5), (5), (3), (3), (3), (2), (2), (2), (2), (1), (1)
Human, Mouse (Murine)
(155), (52), (6), (2), (2)
(123), (49), (7)
(16), (15), (11), (5), (5), (5), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(113), (78), (63), (52), (28), (18), (15), (8), (6), (4), (3), (2), (2), (1), (1)
Pubmed 2 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of mouse TLR6.
Isotype Ig
Specificity This antibody detects TLR6 at N-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name CD286 / TLR6 (TLR6 Antibody Abstract)
Background TLR6, a Type I membrane protein that belongs to the Toll-like rceptor family, participates in the innate immune response to Gram-positive bacteria and fungi. It acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It binds to TLR2 via their respective extracellular domains, and to MyD88 via their respective TIR domains. TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.Synonyms: Toll-like receptor 6
Gene ID 21899, 10090
UniProt Q9EPW9
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling
Application Notes ELISA 1: 1,000. Immunohistochemistry 1: 50 - 1: 100. Western blot 1: 200 - 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Toll-Like Receptor 6 (TLR6) (N-Term) antibody (ABIN357054) anti-Toll-Like Receptor 6 (TLR6) (N-Term) antibody
 image for anti-Toll-Like Receptor 6 (TLR6) (N-Term) antibody (ABIN357054) anti-Toll-Like Receptor 6 (TLR6) (N-Term) antibody (Image 2)
Background publications Ozinsky, Underhill, Fontenot et al.: "The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 25, pp. 13766-71, 2000 (PubMed).

Takeuchi, Kawai, Sanjo et al.: "TLR6: A novel member of an expanding toll-like receptor family." in: Gene, Vol. 231, Issue 1-2, pp. 59-65, 1999 (PubMed).

Catalog No. ABIN357054
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