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Details for Product No. ABIN357748

BMI1 Polycomb Ring Finger Oncogene (BMI1) (C-Term) antibody

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Synonyms FLVI2/BMI1, PCGF4, RNF51, Bmi-1, Pcgf4, AW546694, BMI-1, bmi1, pcgf4, psc1, wu:fb17g03, wu:fd18f06
»Alternatives C-Term
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN357748
Quantity 0.4 mL
346.50 $   Plus shipping costs $45.00
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human BMI.
Specificity This antibody is specific to BMI-1/RNF51 (C-term).
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BMI-1 / RNF51
Background BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.
Alternate names: BMI1, PCGF4, Polycomb group RING finger protein 4, RING finger protein 51
Molecular Weight 36949 Da
Gene ID 648
NCBI Accession 9606
UniProt P35226
Application Notes ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Bárdos, Saurin, Tissot et al.: "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties." in: The Journal of biological chemistry, Vol. 275, Issue 37, pp. 28785-92, 2000 (PubMed).

Dimri, Martinez, Jacobs et al.: "The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells." in: Cancer research, Vol. 62, Issue 16, pp. 4736-45, 2002 (PubMed).

Itahana, Zou, Itahana et al.: "Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1." in: Molecular and cellular biology, Vol. 23, Issue 1, pp. 389-401, 2002 (PubMed).

Xia, Anderson, Diaz et al.: "MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 14, pp. 8342-7, 2003 (PubMed).

Smith, Chanda, Lingbeek et al.: "Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1." in: Molecular cell, Vol. 12, Issue 2, pp. 393-400, 2003 (PubMed).

Alternatives for antigen "BMI1 Polycomb Ring Finger Oncogene (BMI1)", type "Antibodies"
Hosts (91), (31), (10)
Reactivities (119), (58), (42), (20), (19), (18), (9), (6), (6), (3), (2), (1), (1)
Applications (116), (48), (27), (21), (21), (19), (10), (7), (6), (2), (2), (2), (1), (1), (1), (1), (1)
Conjugates (6), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (8), (8), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1)