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Structural Maintenance of Chromosomes 2 (SMC2) (C-Term) antibody

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Antigen
Synonyms CAP-E, CAPE, SMC-2, SMC2L1, 5730502P04Rik, AI255214, AW545314, Fin16, Smc2l1, fb92e05, wu:fb92e05, zeh1628, zgc:55326, xcap-e, SCII
Epitope
C-Term
(12), (7), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(45), (8), (7), (2), (2), (2), (2)
Host
Rabbit
(36), (5), (4), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(45), (11), (6), (3), (2), (2), (2), (1), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SMC2.
Isotype Ig
Specificity This antibody detects SMC2 (C-term).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SMC2 / CAPE (SMC2 Antibody Abstract)
Background SMC2 is a central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.Synonyms: CAP-E, Chromosome-associated protein E, SMC protein 2, SMC-2, SMC2L1, Structural maintenance of chromosomes protein 2, XCAP-E homolog
Molecular Weight 135656 Da
Gene ID 10592
NCBI Accession NP_001036015
UniProt O95347
Application Notes ELISA: 1/1,000. Western Blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Image no. 1 for anti-Structural Maintenance of Chromosomes 2 (SMC2) (C-Term) antibody (ABIN357820) anti-Structural Maintenance of Chromosomes 2 (SMC2) (C-Term) antibody
Background publications Ham, Takakuwa, Rahadiani et al.: "Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma." in: Cancer science, Vol. 98, Issue 7, pp. 1041-7, 2007 (PubMed).

Schmiesing, Ball, Gregson et al.: "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 22, pp. 12906-11, 1998 (PubMed).

Catalog No. ABIN357820
$401.50
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