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Details for Product No. ABIN357820

Structural Maintenance of Chromosomes 2 (SMC2) (C-Term) antibody

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Antigen
Synonyms CAP-E, CAPE, SMC-2, SMC2L1, 5730502P04Rik, AI255214, AW545314, Fin16, Smc2l1, fb92e05, wu:fb92e05, zeh1628, zgc:55326, xcap-e, SCII
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN357820
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SMC2.
Specificity This antibody detects SMC2 (C-term).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SMC2 / CAPE
Background SMC2 is a central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Alternate names: CAP-E, Chromosome-associated protein E, SMC protein 2, SMC-2, SMC2L1, Structural maintenance of chromosomes protein 2, XCAP-E homolog
Molecular Weight 135656 Da
Gene ID 10592
NCBI Accession NP_001036015
UniProt O95347
Application Notes ELISA: 1/1,000. Western Blot: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Schmiesing, Ball, Gregson et al.: "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 22, pp. 12906-11, 1998 (PubMed).

Ham, Takakuwa, Rahadiani et al.: "Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma." in: Cancer science, Vol. 98, Issue 7, pp. 1041-7, 2007 (PubMed).

Alternatives for antigen "Structural Maintenance of Chromosomes 2 (SMC2)", type "Antibodies"
Hosts (40), (5), (3), (2)
Reactivities (45), (18), (15), (3), (2), (2), (2), (2)
Applications (38), (12), (9), (4), (2), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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