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Exosome Component 8 (EXOSC8) (C-Term) antibody

Details for Product No. ABIN357948, Supplier: Login to see
Antigen
  • wu:fb79a10
  • zgc:110381
  • MGC52847
  • MGC132146
  • EXOSC8
  • MGC79733
  • CIP3
  • EAP2
  • OIP2
  • RP11-421P11.3
  • RRP43
  • Rrp43p
  • bA421P11.3
  • p9
  • 2310032N20Rik
  • mKIAA4013
Epitope
C-Term
5
2
2
1
1
1
1
1
Reactivity
Human
26
6
6
Host
Rabbit
15
11
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
21
10
10
8
4
4
3
2
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human EXOSC8.
Isotype Ig
Specificity This antibody detects EXOSC8 (C-term).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name EXOSC8 (EXOSC8 Antibody Abstract)
Background EXOSC8 is a component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. It is required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and has a 3'-5' exonuclease activity.Synonyms: Exosome complex exonuclease RRP43, Exosome component 8, OIP2, Opa-interacting protein 2, RRP43, Ribosomal RNA-processing protein 43, p9
Molecular Weight 29909 Da predicted from amino acid sequence. Theoretical pI: 5.17
Gene ID 11340, 9606
UniProt Q96B26
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Pathways
Application Notes ELISA: 1/1,000. Western Blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-Exosome Component 8 (EXOSC8) (C-Term) antibody (ABIN357948) anti-Exosome Component 8 (EXOSC8) (C-Term) antibody
Background publications Raijmakers, Egberts, van Venrooij et al.: "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring." in: Journal of molecular biology, Vol. 323, Issue 4, pp. 653-63, 2002 (PubMed).

Jiang, Altman: "A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5295-300, 2002 (PubMed).

Raijmakers, Noordman, van Venrooij et al.: "Protein-protein interactions of hCsl4p with other human exosome subunits." in: Journal of molecular biology, Vol. 315, Issue 4, pp. 809-18, 2002 (PubMed).