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Exosome Component 8 (EXOSC8) (C-Term) antibody

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Synonyms wu:fb79a10, zgc:110381, MGC52847, MGC132146, EXOSC8, MGC79733, CIP3, EAP2, OIP2, RP11-421P11.3, RRP43, Rrp43p, bA421P11.3, p9, 2310032N20Rik, mKIAA4013
(5), (2), (2), (1), (1), (1), (1), (1)
(26), (6), (6)
(15), (11)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(21), (10), (10), (8), (4), (4), (3), (2)
Pubmed 3 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human EXOSC8.
Isotype Ig
Specificity This antibody detects EXOSC8 (C-term).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name EXOSC8 (EXOSC8 Antibody Abstract)
Background EXOSC8 is a component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. It is required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and has a 3'-5' exonuclease activity.Synonyms: Exosome complex exonuclease RRP43, Exosome component 8, OIP2, Opa-interacting protein 2, RRP43, Ribosomal RNA-processing protein 43, p9
Molecular Weight 29909 Da predicted from amino acid sequence. Theoretical pI: 5.17
Gene ID 11340, 9606
UniProt Q96B26
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes ELISA: 1/1,000. Western Blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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 image for anti-Exosome Component 8 (EXOSC8) (C-Term) antibody (ABIN357948) anti-Exosome Component 8 (EXOSC8) (C-Term) antibody
Background publications Raijmakers, Egberts, van Venrooij et al.: "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring." in: Journal of molecular biology, Vol. 323, Issue 4, pp. 653-63, 2002 (PubMed).

Jiang, Altman: "A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5295-300, 2002 (PubMed).

Raijmakers, Noordman, van Venrooij et al.: "Protein-protein interactions of hCsl4p with other human exosome subunits." in: Journal of molecular biology, Vol. 315, Issue 4, pp. 809-18, 2002 (PubMed).

Catalog No. ABIN357948
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