Exosome Component 8 (EXOSC8) (C-Term) antibody

Details for Product No. ABIN357948
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Antigen
Synonyms wu:fb79a10, zgc:110381, MGC52847, MGC132146, EXOSC8, MGC79733, CIP3, EAP2, OIP2, RP11-421P11.3, RRP43, Rrp43p, bA421P11.3, p9, 2310032N20Rik, mKIAA4013
Epitope
C-Term
(3), (2), (1), (1), (1), (1)
Reactivity
Human
(16), (3), (3)
Host
Rabbit
(9), (7)
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(14), (7), (7), (5), (4), (3), (2), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN357948
357.50 $
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human EXOSC8.
Isotype Ig
Specificity This antibody detects EXOSC8 (C-term).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name EXOSC8
Background EXOSC8 is a component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. It is required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and has a 3'-5' exonuclease activity.Synonyms: Exosome complex exonuclease RRP43, Exosome component 8, OIP2, Opa-interacting protein 2, RRP43, Ribosomal RNA-processing protein 43, p9
Molecular Weight 29909 Da predicted from amino acid sequence. Theoretical pI: 5.17
Gene ID 11340, 9606
UniProt Q96B26
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes ELISA: 1/1,000. Western Blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
anti-Exosome Component 8 (EXOSC8) (C-Term) antibody anti-Exosome Component 8 (EXOSC8) (C-Term) antibody
Background publications Raijmakers, Noordman, van Venrooij et al.: "Protein-protein interactions of hCsl4p with other human exosome subunits." in: Journal of molecular biology, Vol. 315, Issue 4, pp. 809-18, 2002 (PubMed).

Jiang, Altman: "A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5295-300, 2002 (PubMed).

Raijmakers, Egberts, van Venrooij et al.: "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring." in: Journal of molecular biology, Vol. 323, Issue 4, pp. 653-63, 2002 (PubMed).

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