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Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (N-Term) antibody

Details for Product No. ABIN358687
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Antigen
Synonyms MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, MMP1, AI325305, MT-MMP-1, sabe, Mt1-mmp, mmp-x1, mt1-mmp, mtmmp1
Epitope
N-Term
(27), (10), (9), (8), (4), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(146), (50), (49), (18), (4), (2), (1), (1), (1)
Host
Rabbit
(125), (27), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(121), (63), (41), (36), (27), (14), (14), (12), (8), (7), (3), (2), (1)
Pubmed 2 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN358687
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MMP14.
Specificity This antibody reacts to MMP14.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name MMP-14
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.
Alternate names: MMP-X1, MMP14, Matrix metalloproteinase-14, Membrane-type-1 matrix metalloproteinase
Gene ID 4323
NCBI Accession 9606
UniProt P50281
Research Area Cancer, Extracellular Matrix, Inflammation
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (N-Term) antibody anti-Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (N-Term) antibody
anti-Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (N-Term) antibody (2) anti-Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (N-Term) antibody (Image 2)
Background publications Will, Hinzmann: "cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment." in: European journal of biochemistry / FEBS, Vol. 231, Issue 3, pp. 602-8, 1995 (PubMed).

Takino, Sato, Yamamoto et al.: "Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain." in: Gene, Vol. 155, Issue 2, pp. 293-8, 1995 (PubMed).

Hosts (125), (27), (2), (1)
Reactivities (146), (50), (49), (18), (4), (2), (1), (1), (1)
Applications (121), (63), (41), (36), (27), (14), (14), (12), (8), (7), (3), (2), (1)
Conjugates (4), (4), (4), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (27), (10), (9), (8), (4), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN358687
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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