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MMP14 antibody (Matrix Metallopeptidase 14 (Membrane-inserted)) (N-Term)

Details for Product anti-MMP14 Antibody No. ABIN358687, Supplier: Login to see New
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Synonyms MMP-14, mmp-x1, mt1-mmp, mtmmp1, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, AI325305, MT-MMP-1, sabe, Mt1-mmp, MMP1
(48), (18), (16), (13), (7), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(198), (34), (33), (4), (3), (2), (2), (2), (1), (1)
(158), (31), (10), (3)
This MMP14 antibody is un-conjugated
(8), (8), (8), (6), (6), (6), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(173), (104), (59), (35), (22), (15), (13), (8), (5), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MMP14.
Isotype Ig
Specificity This antibody reacts to MMP14.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name MMP-14 (MMP14 Antibody Abstract)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.Synonyms: MMP-X1, MMP14, Matrix metalloproteinase-14, Membrane-type-1 matrix metalloproteinase
Gene ID 4323, 9606
UniProt P50281
Research Area Cancer, Extracellular Matrix, Inflammation
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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Background publications Takino, Sato, Yamamoto et al.: "Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain." in: Gene, Vol. 155, Issue 2, pp. 293-8, 1995 (PubMed).

Will, Hinzmann: "cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment." in: European journal of biochemistry / FEBS, Vol. 231, Issue 3, pp. 602-8, 1995 (PubMed).

Catalog No. ABIN358687
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