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LMTK2 antibody (Lemur tyrosine Kinase 2) (Middle Region)

Details for Product anti-LMTK2 Antibody No. ABIN359289, Supplier: Login to see New
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Synonyms AATYK2, BREK, KPI-2, KPI2, LMR2, cprk, 2900041G10Rik, A330101P12Rik, aatyk2
Middle Region
(19), (19), (8), (3), (3), (2), (1), (1), (1), (1), (1), (1)
(66), (3), (2), (2), (1), (1), (1)
(43), (13), (10)
This LMTK2 antibody is un-conjugated
(3), (3), (3), (3), (3), (3)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(59), (48), (30), (12), (9), (5), (1)
Pubmed 5 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human LMTK2.
Isotype Ig
Specificity This antibody reacts to LMTK2.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name LMTK2 (LMTK2 Antibody Abstract)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families.Synonyms: AATYK2, Apoptosis-associated tyrosine kinase 2, BREK, Brain-enriched kinase, CDK5/p35-regulated kinase, CPRK, EC=, KIAA1079, KPI2, Kinase/phosphatase/inhibitor 2, LMR2, LMTK2, Lemur tyrosine kinase 2, Serine/threonine protein kinase KPI-2, Serine/threonine-protein kinase LMTK2
Gene ID 22853, 9606
UniProt Q8IWU2
Pathways RTK Signaling, Neurotrophin Signaling Pathway
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-LMTK2 antibody (Lemur tyrosine Kinase 2) (Middle Region) (ABIN359289) Western blot analysis of LMTK2 (arrow) using rabbit polyclonal LMTK2 Antibody
Background publications Kawa, Fujimoto, Tezuka et al.: "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 9, Issue 3, pp. 219-32, 2004 (PubMed).

Hillier, Fulton, Fulton et al.: "The DNA sequence of human chromosome 7. ..." in: Nature, Vol. 424, Issue 6945, pp. 157-64, 2003 (PubMed).

Kesavapany, Lau, Ackerley et al.: "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 23, Issue 12, pp. 4975-83, 2003 (PubMed).

Scherer, Cheung, MacDonald et al.: "Human chromosome 7: DNA sequence and biology. ..." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, 2003 (PubMed).

Wang, Brautigan: "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49605-12, 2002 (PubMed).

Catalog No. ABIN359289
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