Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (N-Term) antibody

Details for Product No. ABIN359711
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Antigen
Synonyms DYRK1A, dyrk, dyrk1, hp86, mnb, mnbh, DYRK, DYRK1, HP86, MNB, MNBH, MRD7, 2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, ENSMUSG00000074897, Gm10783, Mnbh, Mp86, mmb, PSK47
Epitope
N-Term
(18), (18), (7), (7), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(76), (33), (31), (12), (12), (12), (12)
Host
Rabbit
(76), (3), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(73), (38), (11), (10), (8), (6), (5), (3), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
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Catalog No. ABIN359711
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human DYRK1A.
Isotype Ig
Specificity This antibody reacts to DYRK1A.
Purification Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name DYRK1A
Background DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.Synonyms: DYRK, Dual specificity YAK1-related kinase, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, HP86, MNB, MNBH, Protein kinase minibrain homolog
Gene ID 1859, 9606
UniProt Q13627
Research Area Neurology, Neurogenesis
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications Wissing, Jänsch, Nimtz et al.: "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 3, pp. 537-47, 2007 (PubMed).

Alvarez, Altafaj, Aranda et al.: "DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding." in: Molecular biology of the cell, Vol. 18, Issue 4, pp. 1167-78, 2007 (PubMed).

Chang, Lin, Yang et al.: "Increased expression of Dyrk1a in HPV16 immortalized keratinocytes enable evasion of apoptosis." in: International journal of cancer. Journal international du cancer, Vol. 120, Issue 11, pp. 2377-85, 2007 (PubMed).

Adayev, Chen-Hwang, Murakami et al.: "Dual-specificity tyrosine phosphorylation-regulated kinase 1A does not require tyrosine phosphorylation for activity in vitro." in: Biochemistry, Vol. 46, Issue 25, pp. 7614-24, 2007 (PubMed).

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