Thrombopoietin (THPO) (C-Term) antibody

Details for Product No. ABIN359714
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Antigen
Synonyms MGDF, MKCSF, ML, MPLLG, THCYT1, TPO, Ml, Tpo, Mgdf, Tpo1, Tpo2, Tpo3, Tpo4, Mpllg, tpo, LOC100231762
Epitope
C-Term
(3), (3), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(60), (33), (16), (14), (3), (1), (1), (1)
Host
Rabbit
(49), (22), (18), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(72), (61), (20), (17), (10), (10), (6), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1)
Pubmed 3 references available
Catalog no. ABIN359714
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide at the C-term of human THPO.
Specificity This antibody reacts to Thrombopoietin.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name Thrombopoietin
Background Megakaryocytopoiesis is the cellular development process that leads to platelet production. THPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. It is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene.
Alternate names: C-mpl ligand, MGDF, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, Myeloproliferative leukemia virus oncogene ligand, THPO
Gene ID 7066
NCBI Accession 9606
UniProt P40225
Research Area Cancer, Cell Cycle, Hormones
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Kanayasu-Toyoda, Ishii-Watabe, Suzuki et al.: "A new role of thrombopoietin enhancing ex vivo expansion of endothelial precursor cells derived from AC133-positive cells." in: The Journal of biological chemistry, Vol. 282, Issue 46, pp. 33507-14, 2007 (PubMed).

Baker, Su, Hsu et al.: "Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats." in: Cardiovascular research, Vol. 77, Issue 1, pp. 44-53, 2008 (PubMed).

Steinberg, Gilad, Dgany et al.: "Congenital amegakaryocytic thrombocytopenia-3 novel c-MPL mutations and their phenotypic correlations." in: Journal of pediatric hematology/oncology, Vol. 29, Issue 12, pp. 822-5, 2007 (PubMed).

Hosts (49), (22), (18), (6)
Reactivities (60), (33), (16), (14), (3), (1), (1), (1)
Applications (72), (61), (20), (17), (10), (10), (6), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1)
Conjugates (6), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (3), (2), (2), (2), (1), (1), (1)
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