You are viewing an incomplete version of our website. Please click to reload the website as full version.

Tyrosyl-tRNA Synthetase (Yars) (C-Term) antibody

Details for Product No. ABIN359750, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms cmtdic, tyrrs, yrs, yts, YARS, CG4561, Dmel\\CG4561, TyrRS, YRS, anon-EST:Posey261, dYARS, GB10789, ECK1633, JW1629, cb204, wu:fk52b08, CMTDIC, TYRRS, YTS, AL024047, AU018965
(8), (6), (2), (2), (1), (1), (1)
(54), (8), (8), (4), (2), (2), (1)
(45), (9)
(6), (6), (6)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(49), (29), (12), (6), (5), (5), (3), (3), (2), (1), (1), (1)
Pubmed 3 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human YARS.
Isotype Ig
Specificity This antibody reacts to Tyrosyl tRNA synthetase (YARS).
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name YARS (Yars Antibody Abstract)
Background Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.Synonyms: TyrRS, Tyrosyl-tRNA ligase, Tyrosyl-tRNA synthetase cytoplasmic
Gene ID 8565, 9606
UniProt P54577
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Tyrosyl-tRNA Synthetase (Yars) (C-Term) antibody (ABIN359750) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with YARS an...
Western Blotting (WB) image for anti-Tyrosyl-tRNA Synthetase (Yars) (C-Term) antibody (ABIN359750) Western blot analysis of anti-YARS Antibody (C-term) in CEM cell line lysates (35ug/l...
Background publications Yang, Kapoor, Otero et al.: "Gain-of-function mutational activation of human tRNA synthetase procytokine." in: Chemistry & biology, Vol. 14, Issue 12, pp. 1323-33, 2007 (PubMed).

Jordanova, Irobi, Thomas et al.: "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. ..." in: Nature genetics, Vol. 38, Issue 2, pp. 197-202, 2006 (PubMed).

Bonnefond, Fender, Rudinger-Thirion et al.: "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS." in: Biochemistry, Vol. 44, Issue 12, pp. 4805-16, 2005 (PubMed).

Catalog No. ABIN359750
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)