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YARS Products

(Tyrosyl-tRNA Synthetase (Yars))

Categories

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008].

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Featured YARS Categories

YARS Antibodies

High quality antibodies with extensive validation data.

YARS Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended YARS Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IF, IHC, WB
Validations
  • (5)
Cat. No. ABIN7173996
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ICC, IF, IHC (p), WB
Validations
  • (3)
Cat. No. ABIN2855065
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application DB, ICC, FACS, IP, WB
Validations
  • (3)
Cat. No. ABIN933090
Quantity 100 μg
Datasheet Datasheet

Recommended YARS Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3073659
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3073658
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3127390
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our YARS products

Zhang, Zhai, Tang, Cheng, Li, Wang, Zhu: "Quantitative proteome-based systematic identification of SIRT7 substrates." in: Proteomics, Vol. 17, Issue 13-14, (2017) (PubMed).

Wei, Xu, Liu, Lo, Ye, Lau, Wang, Zhou, Nangle, Yang, Zhang, Schimmel: "Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase." in: Nucleic acids research, Vol. 44, Issue 3, pp. 1247-55, (2016) (PubMed).

Niehues, Bussmann, Steffes, Erdmann, Köhrer, Sun, Wagner, Schäfer, Wang, Koerdt, Stum, RajBhandary, Thomas, Aberle, Burgess, Yang, Dieterich, Storkebaum: "Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases." in: Nature communications, Vol. 6, pp. 7520, (2015) (PubMed).

Storkebaum, Leitão-Gonçalves, Godenschwege, Nangle, Mejia, Bosmans, Ooms, Jacobs, Van Dijck, Yang, Schimmel, Norga, Timmerman, Callaerts, Jordanova: "Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 28, pp. 11782-7, (2009) (PubMed).

Yang, Kapoor, Otero, Slike, Tsuruta, Frausto, Bates, Ewalt, Cheresh, Schimmel: "Gain-of-function mutational activation of human tRNA synthetase procytokine." in: Chemistry & biology, Vol. 14, Issue 12, pp. 1323-33, (2007) (PubMed).

Jordanova, Irobi, Thomas, Van Dijck, Meerschaert, Dewil, Dierick, Jacobs, De Vriendt, Guergueltcheva, Rao, Tournev, Gondim, DHooghe, Van Gerwen, Callaerts, Van Den Bosch, Timmermans, Robberecht et al.: "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. ..." in: Nature genetics, Vol. 38, Issue 2, pp. 197-202, (2006) (PubMed).

Bonnefond, Fender, Rudinger-Thirion, Giegé, Florentz, Sissler: "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS." in: Biochemistry, Vol. 44, Issue 12, pp. 4805-16, (2005) (PubMed).

Synonyms and alternative names related to YARS

tyrosyl-tRNA synthetase (YARS), tyrosyl-tRNA synthetase (Yars), tyrosyl-tRNA synthetase (yars), tyrosyl-tRNA synthetase L homeolog (yars.L), tyrosyl-tRNA synthetase, putative (MAL8P1.125), tyrosine--tRNA ligase (MEFER_RS04475), Tyrosyl-tRNA synthetase (TyrRS), tyrosine--tRNA ligase, cytoplasmic (LOC413909), tyrosine--tRNA ligase, cytoplasmic (LOC100163888), tyrosyl-tRNA synthetase (LOC100282315), AL024047, anon-EST:Posey261, AU018965, cb204, CG4561, CMTDIC, cmtdic, Dmel\\CG4561, dYARS, GB10789, TYRRS, tyrrs, TyrRS, wu:fk52b08, YARS, YRS, yrs, YTS, yts

Protein level used designations for YARS

  • tyrosine tRNA ligase 1, cytoplasmic
  • tyrosine--tRNA ligase, cytoplasmic
  • tyrosyl--tRNA ligase
  • tyrosyl-tRNA synthetase, cytoplasmic
  • Tyrosyl-tRNA synthetase, cytoplasmic
  • tyrRS
  • tyrosyl-tRNA synthetase
  • Aats-tyr-PA
  • CG4561-PA
  • ACYPI004940
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