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FGFR3 antibody (Fibroblast Growth Factor Receptor 3) (C-Term)

Details for Product anti-FGFR3 Antibody No. ABIN359858, Supplier: Login to see New
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Synonyms FGFR3, LOC100034114, ACH, CD333, CEK2, HSFGFR3EX, JTK4, FR3, Fgfr-3, Flg-2, HBGFR, Mfr3, sam3, fc27h01, wu:fc27h01
(25), (15), (14), (13), (12), (12), (10), (6), (5), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
(115), (45), (30), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
(126), (5), (1)
This FGFR3 antibody is un-conjugated
(10), (9), (8), (4), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(85), (58), (57), (24), (12), (9), (5), (3), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human FGFR3.
Isotype Ig
Specificity This antibody reacts to FGFR3.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name CD333 / FGFR3 (FGFR3 Antibody Abstract)
Background FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.Synonyms: FGFR-3, Fibroblast growth factor receptor 3, JTK4
Gene ID 2261, 9606
UniProt P22607
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-FGFR3 antibody (Fibroblast Growth Factor Receptor 3) (C-Term) (ABIN359858) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-FGFR3 antibody (Fibroblast Growth Factor Receptor 3) (C-Term) (ABIN359858) Western blot analysis of anti-FGFR3 Pab in Jurkat cell lysate. FGFR3 (Arrow) was dete...
Background publications Sturla, Merrick, Burchill: "FGFR3IIIS: a novel soluble FGFR3 spliced variant that modulates growth is frequently expressed in tumour cells." in: British journal of cancer, Vol. 89, Issue 7, pp. 1276-84, 2003 (PubMed).

Pehlivan, Ozkinay, Okutman et al.: "Achondroplasia in Turkey is defined by recurrent G380R mutation of the FGFR3 gene." in: The Turkish journal of pediatrics, Vol. 45, Issue 2, pp. 99-101, 2003 (PubMed).

Reinhart, Eulert, Bill et al.: "[Typical features of craniofacial growth of the FGFR3-associated coronal synostosis syndrome (so-called Muenke craniosynostosis)]." in: Mund-, Kiefer- und Gesichtschirurgie : MKG, Vol. 7, Issue 3, pp. 132-7, 2003 (PubMed).

Lievens, Liboi et al.: "The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) ..." in: The Journal of biological chemistry, Vol. 278, Issue 19, pp. 17344-9, 2003 (PubMed).

Santra, Zhan, Tian et al.: "A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript." in: Blood, Vol. 101, Issue 6, pp. 2374-6, 2003 (PubMed).

Catalog No. ABIN359858
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