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Fibroblast Growth Factor Receptor 3 (FGFR3) (C-Term) antibody

Details for Product No. ABIN359858
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Antigen
Synonyms ACH, CEK2, JTK4, CD333, HSFGFR3EX, FR3, Fgfr-3, Flg-2, HBGFR, Mfr3, sam3, fc27h01, wu:fc27h01, FGFR3, LOC100034114, ach, cd333, cek2, fgfr-3, hsfgfr3ex, jtk4
Epitope
C-Term
(14), (12), (8), (7), (6), (6), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(80), (50), (39), (24), (24), (12), (3), (1), (1), (1)
Host
Rabbit
(91), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(55), (36), (33), (30), (20), (4), (3), (3), (1), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN359858
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human FGFR3.
Specificity This antibody reacts to FGFR3.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name CD333 / FGFR3
Background FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full- length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
Alternate names: FGFR-3, Fibroblast growth factor receptor 3, JTK4
Gene ID 2261
NCBI Accession 9606
UniProt P22607
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Santra, Zhan, Tian et al.: "A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript." in: Blood, Vol. 101, Issue 6, pp. 2374-6, 2003 (PubMed).

Lievens, Liboi: "The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum." in: The Journal of biological chemistry, Vol. 278, Issue 19, pp. 17344-9, 2003 (PubMed).

Reinhart, Eulert, Bill et al.: "[Typical features of craniofacial growth of the FGFR3-associated coronal synostosis syndrome (so-called Muenke craniosynostosis)]." in: Mund-, Kiefer- und Gesichtschirurgie : MKG, Vol. 7, Issue 3, pp. 132-7, 2003 (PubMed).

Pehlivan, Ozkinay, Okutman et al.: "Achondroplasia in Turkey is defined by recurrent G380R mutation of the FGFR3 gene." in: The Turkish journal of pediatrics, Vol. 45, Issue 2, pp. 99-101, 2003 (PubMed).

Sturla, Merrick, Burchill: "FGFR3IIIS: a novel soluble FGFR3 spliced variant that modulates growth is frequently expressed in tumour cells." in: British journal of cancer, Vol. 89, Issue 7, pp. 1276-84, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN359858
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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