Bromodomain Containing 2 (BRD2) (Middle Region) antibody

Details for Product No. ABIN360494
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Antigen
Synonyms D6S113E, FSH, FSRG1, NAT, RING3, RNF3, AW228947, D17H6S113E, Frg-1, Fsrg-1, Fsrg1, Nat, Ring3, Rnf3, mKIAA4005, brd2-a, fsh, fsrg1, nat, ring3, rnf3, brd2, fe47f02, fi85h05, wu:fe47f02, wu:fi85h05
Epitope
Middle Region
(8), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(51), (16), (15), (14), (14), (14), (14), (1), (1)
Host
Rabbit
(41), (8), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(40), (12), (10), (9), (8), (7), (4), (4), (4), (2), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN360494
357.50 $
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human BRD2.
Specificity This antibody reacts to BRD2.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name BRD2
Background BRD2 is a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human protein may be part of a signal transduction pathway involved in growth control.
Alternate names: Bromodomain-containing protein 2, KIAA9001, O27.1.1, RING3
Gene ID 6046, 9606
UniProt P25440
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Proteolysis / Ubiquitin
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Bromodomain Containing 2 (BRD2) (Middle Region) antibody anti-Bromodomain Containing 2 (BRD2) (Middle Region) antibody
anti-Bromodomain Containing 2 (BRD2) (Middle Region) antibody (2) anti-Bromodomain Containing 2 (BRD2) (Middle Region) antibody (Image 2)
Background publications Taniguchi, Matsuzaka, Fujimoto et al.: "Nucleotide sequence of the ring3 gene in the class II region of the mouse MHC and its abundant expression in testicular germ cells." in: Genomics, Vol. 51, Issue 1, pp. 114-23, 1998 (PubMed).

Denis, Vaziri, Guo et al.: "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 11, Issue 8, pp. 417-24, 2000 (PubMed).

Crowley, Kaine, Yoshida et al.: "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein." in: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 8, pp. 1727-37, 2002 (PubMed).

Pal, Evgrafov, Tabares et al.: "BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy." in: American journal of human genetics, Vol. 73, Issue 2, pp. 261-70, 2003 (PubMed).

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