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Details for Product No. ABIN360840

Dual Specificity Phosphatase 3 (DUSP3) (N-Term) antibody

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Antigen
Synonyms VHR, T-DSP11, 2210015O03Rik, 5031436O03Rik, RGD1560049, dusp3, si:bz18k17.3, si:rp71-18k17.3
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN360840
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human DUSP3.
Specificity This antibody reacts to DUSP3.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name DUSP3
Background DUSP3 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
Alternate names: Dual specificity protein phosphatase 3, Dual specificity protein phosphatase VHR, VHR, Vaccinia H1-related phosphatase
Gene ID 1845
NCBI Accession 9606
UniProt P51452
Research Area Cancer, Metabolism, Amino Acids
Application Notes ELISA: 1/1,000. Western Blot: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Kamb, Futreal, Rosenthal et al.: "Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1." in: Genomics, Vol. 23, Issue 1, pp. 163-7, 1995 (PubMed).

Folander, Douglass, Swanson: "Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1." in: Genomics, Vol. 23, Issue 1, pp. 295-6, 1995 (PubMed).

Todd, Tanner, Denu: "Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway." in: The Journal of biological chemistry, Vol. 274, Issue 19, pp. 13271-80, 1999 (PubMed).

Alonso, Saxena, Williams et al.: "Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4766-71, 2001 (PubMed).

Alonso, Rahmouni, Williams et al.: "Tyrosine phosphorylation of VHR phosphatase by ZAP-70." in: Nature immunology, Vol. 4, Issue 1, pp. 44-8, 2002 (PubMed).

Alternatives for antigen "Dual Specificity Phosphatase 3 (DUSP3)", type "Antibodies"
Hosts (30), (10)
Reactivities (40), (14), (13), (12), (12)
Applications (27), (17), (10), (9), (6), (3), (2), (2), (2), (2), (1), (1)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (3), (3), (2), (2), (2), (2), (1)
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