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Details for Product No. ABIN361845

RAB5A, Member RAS Oncogene Family (RAB5A) antibody

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Synonyms RAB5, 2410015H04Rik, AI663973, AU021172, nnyRab5a, DDBDRAFT_0168594, DDBDRAFT_0229401, DDB_0168594, DDB_0229401, rab5, RAB5A
»Alternatives Human, Mouse (Murine), Monkey, Cow (Bovine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 6 references available
Catalog no. ABIN361845
Quantity 25 µg
220.70 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Human Rab5 synthetic peptide conjugated to KLH identical to dog Rab5 sequence over the AA
Specificity The antibody recognizes 26 kDa Rab5 of the above species origins.
Purification Affinity Purified
Alternative Name Rab5
Background Synonyms:
Rab 5A, RAS associated protein RAB5A, Ras related protein Rab 5 A
Rab5 is a 24 kDa member of the Rab family of small guanosine triphosphatases (GTPases), Ras superfamily. Rab GTPases are central regulators of membrane trafficking in the eukaryotic cell. Their regulatory capacity depends on their ability to cycle between the GDP-bound inactive and GTP-bound active states. This conversion is regulated by GDP/GTP exchange factors (GEPs), GDP dissociation inhibitors (GDIs) and GTPase-activating proteins (GAPs). Activation of a Rab protein is coupled to its association with intracellular membranes, allowing it to recruit downstream effector proteins to the cytoplasmic surface of a subcellular compartment. Through these proteins, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion. Rab proteins contain conserved regions involved in guanine-nucleotide binding, and hyper variable COHO-terminal domains with a cysteine motif implicated in subcellular targeting. Post-translational modification of the cysteine motif with one or two geranyl groups is essential for the membrane association and correct intracellular localization of Rab proteins. Each Rab shows a characteristic subcellular distribution.In particular, Rab5 is ubiquitously expressed in human tissues. It localizes mainly to early endosomes, but is also present on the plasma membrane. It regulates the fusion between endocytic vesicles and early endosomes, as well as the homotypic fusion between early endosomes. Among the proteins recruited by the GTP-bound active Rab5 are Rabaptin-5 and EEA1. Anti-Rab5 may be used as an early endosome marker.
Gene ID 5868
NCBI Accession NP_004153.2
UniProt Q6FI44
Research Area Neurology, Organelles, Signaling, Cell Signaling
Application Notes Recommended Dilution: 1:1000 (WB)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Storage -20 °C
Background publications Sönnichsen, De Renzis, Nielsen et al.: "Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11." in: The Journal of cell biology, Vol. 149, Issue 4, pp. 901-14, 2000 (PubMed).

Woodman: "Biogenesis of the sorting endosome: the role of Rab5." in: Traffic (Copenhagen, Denmark), Vol. 1, Issue 9, pp. 695-701, 2001 (PubMed).

Zerial, McBride: "Rab proteins as membrane organizers." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 2, pp. 107-17, 2001 (PubMed).

Ali, Wasmeier, Lamoreux et al.: "Multiple regions contribute to membrane targeting of Rab GTPases." in: Journal of cell science, Vol. 117, Issue Pt 26, pp. 6401-12, 2004 (PubMed).

Takai, Sasaki, Matozaki: "Small GTP-binding proteins." in: Physiological reviews, Vol. 81, Issue 1, pp. 153-208, 2001 (PubMed).

Stenmark, Olkkonen: "The Rab GTPase family." in: Genome biology, Vol. 2, Issue 5, pp. REVIEWS3007, 2001 (PubMed).

Alternatives for antigen "RAB5A, Member RAS Oncogene Family (RAB5A)", type "Antibodies"
Hosts (59), (20), (4), (4)
Reactivities (78), (52), (40), (25), (19), (16), (11), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2)
Applications (75), (27), (14), (10), (10), (8), (6), (3), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (9), (6), (4), (3), (3), (2), (2), (2), (1)