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GRP78 antibody (C-Term)

HSPA5 Reactivity: Rat, Mouse WB, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN363672
  • Target See all GRP78 (HSPA5) Antibodies
    GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))
    Binding Specificity
    • 21
    • 16
    • 13
    • 8
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 600-654, C-Term
    Reactivity
    • 195
    • 122
    • 105
    • 36
    • 35
    • 34
    • 32
    • 30
    • 30
    • 20
    • 14
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat, Mouse
    Host
    • 135
    • 96
    • 8
    • 3
    • 1
    • 1
    Rabbit
    Clonality
    • 139
    • 106
    Polyclonal
    Conjugate
    • 98
    • 19
    • 16
    • 12
    • 12
    • 12
    • 9
    • 8
    • 8
    • 8
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This GRP78 antibody is un-conjugated
    Application
    • 212
    • 99
    • 86
    • 79
    • 76
    • 34
    • 28
    • 27
    • 26
    • 21
    • 13
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    Reacts with rat and mouse 78 kDa GRP-78 protein
    Cross-Reactivity (Details)
    Weakly cross reacts with human GRP-78.
    Purification
    Antigen affinity purified
    Immunogen
    Synthetic peptide derived from C-term domain of the rat Grp78 protein. Within residues 600-654.
    Top Product
    Discover our top product HSPA5 Primary Antibody
  • Application Notes

    Working dilution: Optimal dilution should be determined by the end user.
    The following are guidelines only:
    WB0.5 μg/mL ICC/IF1:50

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.05 mg/mL
    Buffer
    PBS, glycerol 30 % , Sodium azide 0.1 %
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
    Expiry Date
    6 months
  • Target
    GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))
    Alternative Name
    78 kDa Glucose-Regulated Protein (GRP-78) (HSPA5 Products)
    Background
    Categorized as stress response proteins, BiPs play an important role in folding and assembly of nascent proteins and in scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5- nontranslated region of BiP mRNA. BiP IRES activity increases when cells are heat-stressed. GRP78 is also important in maintenance of cell homeostasis and the prevention of apoptosis. Levels of GRP78 protein are reduced in brains of Alzheimer's disease patients.
    Gene ID
    25617
    Pathways
    Thyroid Hormone Synthesis, ER-Nucleus Signaling
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