Did you know that you can buy products from over 140 different suppliers from us?

CD40 Ligand (CD40LG) antibody (PE)

Details for Product No. ABIN370949
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms CD154, cd40l, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40-L, Cd40l, Ly-62, Ly62, Tnfsf5
Reactivity
Mouse (Murine)
(233), (119), (32), (9), (5), (3), (3), (1)
Host
Hamster
(126), (84), (80), (18), (13), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
PE
(44), (32), (16), (5), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(169), (125), (85), (41), (34), (30), (25), (21), (17), (10), (6), (6), (4), (3), (3), (1)
Pubmed 7 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN370949
308.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Clone MR1
Isotype IgG
Characteristics Synonyms: CD40 ligand, CD40-L, CD40LG, TNFSF5, TRAP, GP39, Tumor necrosis factor ligandsuperfamily member 5, TNF-related activation protein, T-cell antigen Gp39
Alternative Name CD154 / CD40L
Background CD154, formerly known as CD40 ligand and gp39, is a type II integral membrane proteinand a member of the tumor necrosis factor (TNF) family of ligands. (Ref. 1-7) It is animportant accessory molecule in T cell-B cell costimulatory interactions, and is expressedpredominantly on activated CD4+ T lymphocytes. It is also present on the surface ofactivated Th0, Th1, and Th2 T cell clones. Its expression is transient andcyclosporinsensitive. (Ref. 6) The MR1 monoclonal antibody binds to murine CD154 withhigh affinity, blocks binding to CD40, and blocks CD154 function. (Ref. 1,5) Administrationof this antibody to mice blocks the ability to mount primary and secondary immuneresponses to TD antigens, yet does not alter the immune response to TI antigens. (Ref. 4)
UniProt P27548
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: < / 2 µg/10e6 cells. (Ref.1,5)Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Armitage, Fanslow, Strockbine et al.: "Molecular and biological characterization of a murine ligand for CD40." in: Nature, Vol. 357, Issue 6373, pp. 80-2, 1992 (PubMed).

Noelle, Roy, Shepherd et al.: "A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 14, pp. 6550-4, 1992 (PubMed).

Hollenbaugh, Grosmaire, Kullas et al.: "The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity." in: The EMBO journal, Vol. 11, Issue 12, pp. 4313-21, 1992 (PubMed).

Foy, Page, Waldschmidt et al.: "An essential role for gp39, the ligand for CD40, in thymic selection." in: The Journal of experimental medicine, Vol. 182, Issue 5, pp. 1377-88, 1995 (PubMed).

Aruffo, Farrington, Hollenbaugh et al.: "The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome." in: Cell, Vol. 72, Issue 2, pp. 291-300, 1993 (PubMed).

Foy, Shepherd, Durie et al.: "In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39." in: The Journal of experimental medicine, Vol. 178, Issue 5, pp. 1567-75, 1993 (PubMed).

Roy, Waldschmidt, Aruffo et al.: "The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 5, pp. 2497-510, 1993 (PubMed).

Validation Images
back to top