CD24 antibody

Catalog No. ABIN371113

Product Details anti-CD24 Antibody

Target: CD24 (CD24 Molecule (CD24))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD24 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificity: This antibody recognises CD24/Heat Stable Antigen (HSA).

Characteristics: Synonyms: X62 heat stable antigen, HSA, Signal transducer CD24, Small cell lung carcinoma cluster 4antigen

Purification: Purified

Clone: 30-F1

Isotype: IgG2c

Application Details

Application Notes: Flow Cytometry and Cell Sorting. (Ref.3,4,7-10)Immunoprecipitation. (Ref.3)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD24

Target: CD24 (CD24 Molecule (CD24))

Alternative Name: CD24 (CD24 Products)

Background: CD24 (also known as heat stable antigen) is a phosphatidylinositol linked cell surface glycoprotein with a polypeptide core of 30 amino acids and high carbohydrate content. The apparent molecular mass of the two forms of CD24 purified from a mouse lymphoma cell line appear to be in the range of 40-60 and 23-30 kDa. CD24 is expressed at all stages of B cell development and on most thymocytes. The absence of expression from mature T cells is closely associated with their maturation from CD4+ CD8+ CD24+ thymocytes to either CD4+ CD8- CD24- or CD4- CD8+ CD24- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes. Its ligand is P selectin (CD62P). CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes. CD24 is also a positive marker of pancreatic cancer.Synonyms: HSA, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, X62 heat stable antigen

Gene ID: 12484

UniProt: P24807

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation