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Keratin 19 (KRT19) (C-Term) antibody

Details for Product No. ABIN371616, Supplier: Login to see
Antigen
  • k19
  • ck19
  • k1cs
  • krt9
  • krt15
  • MGC76282
  • MGC83069
  • KRT19
  • CK19
  • K19
  • K1CS
  • GK-19
  • Ka19
  • Krt1-19
  • AI663979
  • EndoC
  • Krt-1.19
Epitope
C-Term
65
44
21
15
13
10
10
9
8
8
8
7
6
6
5
5
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mammalian
521
74
51
7
7
6
4
3
3
3
2
1
1
Host
Mouse
326
196
18
5
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
30
18
12
6
6
6
2
2
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
363
205
202
187
97
74
64
58
55
12
8
4
3
3
2
1
1
1
1
1
1
1
1
Supplier
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Immunogen Recombinant C-terminal keratin 19.
Clone SB39g
Isotype IgG2a
Specificity This antibody reacts specifically specifically with cytokeratin 19 and recombinant C-terminal keratin 19. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. The degree of cytokeratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Cytokeratin 19 is also associated with malignant transformation in esophageal and pancreatic cancers. (Ref.8,9)
Characteristics Synonyms: Cytokeratin-19, Keratin-19, KRT19, CK19, K19, Keratin type I cytoskeletal 19
Purification Purified
Alternative Name Cytokeratin 19 (KRT19 Antibody Abstract)
Background Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8). The two keratin types share only 30 % sequence homology. (Ref.1-5) Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 19 is the smallest human keratin, is found in many simple and some non-keratinizing stratified squamous epithelia, and is often co-expressed with keratin 7.(Ref.6,7) Cytokeratin 19 has been implicated as a marker for stem cells in some tissues, such as hair follicles in the skin.Synonyms: CK19, Cytokeratin-19, K19, KRT19, Keratin type I cytoskeletal 19, Keratin-19
Gene ID 3880
UniProt P08727
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Pathways
Application Notes ELISA. Western Blot: 1/2,000-1/4,000. Immunohistochemistry (Acetone-Fixed, Frozen Tissue Sections): 10 μg/mL
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer 100 mM Borate buffered saline, pH 8.0 without preservatives or amine-containing buffer salts.
Preservative Without preservative
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Immunofluorescence (IF) image for anti-Keratin 19 (KRT19) (C-Term) antibody (ABIN371616) anti-Keratin 19 (KRT19) (C-Term) antibody
Background publications Wu, Nishioka, Fujita et al.: "Expression of cytokeratin 19 in human hepatocellular carcinoma cell lines." in: International journal of oncology, Vol. 20, Issue 1, pp. 31-7, 2001 (PubMed).

Schiller, Franke, Geiger: "A subfamily of relatively large and basic cytokeratin polypeptides as defined by peptide mapping is represented by one or several polypeptides in epithelial cells." in: The EMBO journal, Vol. 1, Issue 6, pp. 761-9, 1984 (PubMed).

Franke, Schiller, Hatzfeld et al.: "Protein complexes of intermediate-sized filaments: melting of cytokeratin complexes in urea reveals different polypeptide separation characteristics." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 23, pp. 7113-7, 1984 (PubMed).

Hanukoglu, Fuchs: "The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins." in: Cell, Vol. 33, Issue 3, pp. 915-24, 1983 (PubMed).

Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

Tseng, Jarvinen, Nelson et al.: "Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies." in: Cell, Vol. 30, Issue 2, pp. 361-72, 1983 (PubMed).

Fuchs, Coppock, Green et al.: "Two distinct classes of keratin genes and their evolutionary significance." in: Cell, Vol. 27, Issue 1 Pt 2, pp. 75-84, 1982 (PubMed).

Bosch, Leube, Achtstätter et al.: "Expression of simple epithelial type cytokeratins in stratified epithelia as detected by immunolocalization and hybridization in situ." in: The Journal of cell biology, Vol. 106, Issue 5, pp. 1635-48, 1988 (PubMed).