Mitogen-Activated Protein Kinase 14 (MAPK14) (pThr180), (pTyr182) antibody

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Antigen
Synonyms
P38C-CRK, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, CRK1, Csbp1, Csbp2, Exip, Hog, Prkm14, Prkm15, Sapk2A, p38Hog, p38alpha, Crk1, p38-alpha, p38MAPK, p38a, csb ... show more
P38C-CRK, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, CRK1, Csbp1, Csbp2, Exip, Hog, Prkm14, Prkm15, Sapk2A, p38Hog, p38alpha, Crk1, p38-alpha, p38MAPK, p38a, csbp, mapk14a, mxi2, sapk2, sapk2a, p38b, zp38b, MAPK14, 186F5S, BG:DS00797.3, CG7393, D-p38, D-p38 MAPK, D-p38b, Dm p38b, Dmel\\CG7393, Dmp38b, Dp38, Dp38b, ESTS:186F5S, Mpk34C, anon-sts23, dp38b, p38 MAPK, p38 beta, p38B, p38Kb, p38beta show less
Epitope
pThr180, pTyr182
(88), (73), (18), (16), (16), (13), (13), (9), (6), (6), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio)
(312), (218), (214), (76), (47), (41), (14), (10), (6), (5), (5), (5), (5), (2), (1), (1), (1)
Host
Rabbit
(287), (37), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(257), (113), (86), (53), (50), (45), (23), (19), (9), (8), (8), (3), (3), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN372694
Quantity 0.1 mL
Price
390.50 $   Plus shipping costs $45.00
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Immunogen Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr180 and phospho-Tyr182 of rat p38 MAPK.
Isotype IgG
Specificity This antibody recognizes the ~39k p38 MAPK protein phosphorylated at Thr180/Tyr182. Immunolabeling is blocked by preadsorption of the antibody with the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
Purification Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
Alternative Name MAP kinase p38 alpha / MAPK14
Background The three Mitogen-Activated Protein Kinases (MAPKs) are evolutionarily conserved protein kinases that control a vast array of cellular processes. p38 MAPK is one of these kinases and it is activated by both inflammatory cytokines and by stress (Johnson and Lapadat, 2002, Shi and Gaestel, 2002). The p38 MAPK is thought to be particularly important in diseases like asthma and autoimmunity but it also plays important roles in the stress response of the nervous system (Philip and Armstead, 2003, Ying et al., 2002). Like the other MAPKs, p38 is activated by a dual specificity kinase that phosphorylates Thr180 and Tyr182 (Lin et al., 1995).
Alternate names: CSBP, CSBP1, CSBP2, CSPB1, Cytokine suppressive anti-inflammatory drug-binding protein, MAX-interacting protein 2, MXI2, Mitogen-activated protein kinase 14, SAPK2A, p38 alpha
Gene ID 1432
NCBI Accession NP_001306.1
UniProt Q16539
Research Area Kinases/Phosphatases
Application Notes Western blot: 1/1000. Immunohistochemistry: 1/250-1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at-20°C.
Expiry Date 12 months
Supplier Images
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (pThr180), (pTyr182) antibody anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (pThr180), (pTyr182) antibody
Background publications Lin, Minden, Martinetto et al.: "Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2." in: Science (New York, N.Y.), Vol. 268, Issue 5208, pp. 286-90, 1995 (PubMed).

Ying, Futter, Rosenblum et al.: "Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 5, pp. 1532-40, 2002 (PubMed).

Shi, Gaestel: "In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance." in: Biological chemistry, Vol. 383, Issue 10, pp. 1519-36, 2002 (PubMed).

Johnson, Lapadat: "Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases." in: Science (New York, N.Y.), Vol. 298, Issue 5600, pp. 1911-2, 2002 (PubMed).

Philip, Armstead: "Differential role of PTK, ERK and p38 MAPK in superoxide impairment of NMDA cerebrovasodilation." in: Brain research, Vol. 979, Issue 1-2, pp. 98-103, 2003 (PubMed).

Hosts (287), (37), (2), (1)
Reactivities (312), (218), (214), (76), (47), (41), (14), (10), (6), (5), (5), (5), (5), (2), (1), (1), (1)
Applications (257), (113), (86), (53), (50), (45), (23), (19), (9), (8), (8), (3), (3), (2), (2), (1), (1), (1), (1)
Conjugates (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (88), (73), (18), (16), (16), (13), (13), (9), (6), (6), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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