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Details for Product No. ABIN374570

Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) (Internal Region) antibody

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Synonyms HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, OPTA1, VBCH2, mKIAA4142, Xlrp5, bmnd1, evr1, evr4, hbm, lr3, lrp5-A, lrp7, oppg, ops, opta1, vbch2, LRP5, LRP6
»Alternatives Internal Region
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 1 reference available
Catalog no. ABIN374570
Quantity 0.1 mg
346.50 $   Plus shipping costs $45.00
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Immunogen Peptide with sequence C-ERVEKTTGDKRT, from the internal region of the protein sequence Genename: LRP5
Specificity This antibody recognizes LRP5. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse and Rat.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Alternative Name LRP5
Background LRP5 is involved in the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Defects in LRP5 are a cause of autosomal dominant and autosomal recessive familial exudative vitreoretinopathy (FEVR). Autosomal dominant FEVR is also referred to as exudative vitreoretinopathy 1 (EVR1), also known as Criswick-Schepens syndrome. FEVR is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. FEVR is reported to have a penetrance of 100%, but clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease-related abnormality is an arc of avascular retina in the extreme temporal periphery.
Alternate names: LRP-5, LRP7, Low-density lipoprotein receptor-related protein 5
Gene ID 4041
NCBI Accession 9606
UniProt O75197
Research Area Stem Cells, Wnt, Extracellular Matrix
Application Notes Peptide ELISA: Detection Limit: 1/128000. Immunohistochemistry: 3-6 µg/ml. In Paraffin Embedded Human Kidney shows primarily nuclear envelope staining in PCT-. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications He, Semenov, Tamai et al.: "LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way." in: Development (Cambridge, England), Vol. 131, Issue 8, pp. 1663-77, 2004 (PubMed).

Alternatives for antigen "Low Density Lipoprotein Receptor-Related Protein 5 (LRP5)", type "Antibodies"
Hosts (45), (13), (5), (1)
Reactivities (59), (38), (26), (24), (24), (12), (12)
Applications (39), (25), (20), (13), (4), (4), (3), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (13), (11), (4), (2), (2), (2), (2), (1), (1)