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LRP5 antibody (Low Density Lipoprotein Receptor-Related Protein 5) (Internal Region)

Details for Product anti-LRP5 Antibody No. ABIN374570, Supplier: Login to see New
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Synonyms Xlrp5, bmnd1, evr1, evr4, hbm, lr3, lrp5-A, lrp7, oppg, ops, opta1, vbch2, LRP5, LRP6, BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2, mKIAA4142
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Internal Region
(41), (16), (13), (13), (13), (12), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(99), (58), (38), (1), (1), (1), (1), (1)
(91), (15), (12), (2)
This LRP5 antibody is un-conjugated
(8), (8), (7), (5), (5), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(77), (60), (32), (23), (13), (5), (3), (3), (2), (2), (2)
Pubmed 1 reference available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide with sequence C-ERVEKTTGDKRT, from the internal region of the protein sequence Genename: LRP5
Specificity This antibody recognizes LRP5.
Cross-Reactivity (Details) Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Alternative Name LRP5 (LRP5 Antibody Abstract)
Background LRP5 is involved in the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Defects in LRP5 are a cause of autosomal dominant and autosomal recessive familial exudative vitreoretinopathy (FEVR). Autosomal dominant FEVR is also referred to as exudative vitreoretinopathy 1 (EVR1), also known as Criswick-Schepens syndrome. FEVR is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. FEVR is reported to have a penetrance of 100 % , but clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease-related abnormality is an arc of avascular retina in the extreme temporal periphery.Synonyms: LRP-5, LRP7, Low-density lipoprotein receptor-related protein 5
Gene ID 4041, 9606
UniProt O75197
Research Area Stem Cells, Wnt, Extracellular Matrix, Wnt Signaling
Pathways WNT Signaling
Application Notes Peptide ELISA: Detection Limit: 1/128000. Immunohistochemistry: 3-6 μg/mL. In Paraffin Embedded Human Kidney shows primarily nuclear envelope staining in PCT-.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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 image for anti-LRP5 antibody (Low Density Lipoprotein Receptor-Related Protein 5) (Internal Region) (ABIN374570) anti-Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) (Internal Region) antibody
Background publications He, Semenov, Tamai et al.: "LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way." in: Development (Cambridge, England), Vol. 131, Issue 8, pp. 1663-77, 2004 (PubMed).

Catalog No. ABIN374570
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