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Details for Product No. ABIN374716

Unc-13 Homolog D (C. Elegans) (UNC13D) (Internal Region) antibody

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Antigen
Synonyms 2610108D09Rik, Jinx, Munc13-4, mFLJ00067, Unc13h4, FHL3, HLH3, HPLH3, UNC13D
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
Host
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN374716
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide with sequence C-ETQKHKKDLHPLFD, from the internal region of the protein sequence
Specificity This antibody reacts to Munc13-4 / UNC13D. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Canine.
Purification Affinity chromatography
Alternative Name UNC13D
Background Secretion of the contents of cytolytic granules at the immunologic synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Munc 13-4 localises with cytotoxic granules at the immunologic synapse. Munc 13-4 is essential for the priming step of cytolytic granule secretion preceding vesicle membrane fusion. There are two named isoforms.
Alternate names: Munc13-4, Protein unc-13 homolog D
Gene ID 201294
NCBI Accession 9606
UniProt Q70J99
Application Notes ELISA: 1/128000. Western Blot: 1 - 3 µg/ml. Immunohistochemistry on paraffin sections: 2.5 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Zur Stadt, Beutel, Kolberg et al.: "Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A." in: Human mutation, Vol. 27, Issue 1, pp. 62-8, 2005 (PubMed).

Alternatives for antigen "Unc-13 Homolog D (C. Elegans) (UNC13D)", type "Antibodies"
Hosts (16), (8), (5)
Reactivities (26), (6), (4), (3), (1), (1)
Applications (19), (18), (9), (3), (2), (1), (1)
Epitopes (6), (4), (2), (2), (1), (1)
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