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Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) (Internal Region) antibody

Details for Product No. ABIN374796
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Antigen
Synonyms APBA1, 6430513E09Rik, Lin-10, Mint, Mint1, Urop11, X11, X11alpha, D9S411E, LIN10, MINT1, X11A, X11ALPHA
Epitope
Internal Region
(15), (5), (5), (2), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(50), (38), (34), (12), (12), (12), (12)
Host
Goat
(52), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(42), (30), (13), (10), (7), (2), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN374796
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Immunogen Peptide from the internal region of the protein sequence according to NP_001154.2. Genename: APBA1
Sequence C-EASHPSQDGKRQYK
Specificity This antibody detects APBA1 / MINT1. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name APBA1 / MINT1
Background APBA1 is part of two multimeric complexes, the first containing Munc18-1 and syntaxin 1 and the second being a brain specific heterotrimeric complex with LIN-10/X11-alpha, LIN-2/CASK, and LIN7. It binds to the cytoplasmic domain of amyloid protein (APP). ABPA1 has a putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. It may modulate processing of the beta amyloid precursor protein (APP) and hence formation of beta APP. The munc-18 interacting (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three Mint isoforms, Mint 1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint 1 and 2 appear to be expressed exclusively in the brain and are found to bind to Munc18, an essential component of the synaptic vesicle fusion machinery. Mint 3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that Mint3 does not interact with munc-18. Mint 3 has been found to interact with the Alzheimer's Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that Mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer’s disease.
Alternate names: Adapter protein X11alpha, Amyloid beta A4 precursor protein-binding family A member 1, Neuron-specific X11 protein, Neuronal Munc18-1-interacting protein 1
Gene ID 320
NCBI Accession 9606
UniProt Q02410
Application Notes Peptide ELISA: Detection Limit: 1/16000. Western blot: 0.1-0.3 µg/ml. Approx 100kDa band observed in Human Brain (Cerebellumand Hippocampus) lysates (calculated MW of 92.9kDa according to NP_001154.2). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) (Internal Region) antibody anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) (Internal Region) antibody
Background publications Jacobs, Williams, Francis: "Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease." in: Neuroscience, Vol. 138, Issue 2, pp. 511-22, 2006 (PubMed).

Validation Images
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