APBA1 antibody (N-Term)

Catalog No. ABIN2792284

Product Details anti-APBA1 Antibody

Target: APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APBA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PPQQQHYVGR HQRGRALEDL RAQLGQEEEE RGECLARSAS TESGFHNHTD

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against APBA1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human APBA1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 837 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for APBA1

Target: APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))

Alternative Name: APBA1 (APBA1 Products)

Synonyms: APBA1 antibody, 6430513E09Rik antibody, Lin-10 antibody, Mint antibody, Mint1 antibody, Urop11 antibody, X11 antibody, X11alpha antibody, D9S411E antibody, LIN10 antibody, MINT1 antibody, X11A antibody, X11ALPHA antibody, amyloid beta precursor protein binding family A member 1 antibody, amyloid beta (A4) precursor protein-binding, family A, member 1b antibody, ketopantoate reductase antibody, 2-dehydropantoate 2-reductase antibody, amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) antibody, amyloid beta (A4) precursor protein-binding, family A, member 1 antibody, amyloid beta (A4) precursor protein binding, family A, member 1 antibody, APBA1 antibody, apba1b antibody, apbA1 antibody, apba1 antibody, Apba1 antibody

Background: APBA1 is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. APBA1 is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
Alias Symbols: D9S411E, MINT1, X11, X11A, X11ALPHA, LIN10
Protein Interaction Partner: STXBP1, CNTNAP4, NRXN1, CNTNAP3, KIF17, LIN7B, KCNJ12, CCS, CACNA1B, HTR2C, CASK, NOTCH1, STX1A, APP, PSEN1, LIN7A, PSEN2, LIN7C, DLG1, APBB1,
Protein Size: 837

Molecular Weight: 93 kDa

Gene ID: 320

NCBI Accession: NM_001163

UniProt: Q02410

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport