Activin Receptor Type 1 (ACRV1) (Internal Region) antibody

Details for Product No. ABIN374913
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Internal Region
(3), (3), (1), (1), (1), (1)
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(12), (10), (4), (1), (1)
(11), (2), (1)
Western Blotting (WB)
(13), (10), (7), (1)
Pubmed 1 reference available
Catalog no. ABIN374913
Quantity 0.1 mg
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Immunogen Peptide with sequence C-RKFKRRNQERLNPRD, from the internal region of the protein sequence
Specificity This antibody reacts to ACVR1. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Canine.
Purification Affinity chromatography
Background Activin Receptor Type IA on ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Activin receptor IA is highly conserved and is a receptor for BMP2 and BMP4. Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ligands. This family of cytokines and hormones inlude activin, Anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal. They are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions. There are three type I Activin receptors:ACVR1, ACVR1B, and ACVR1C Each bind to a specific type II receptor-ligand complex. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a Type two receptor, which recruits and trans-phosphorylate a type I receptor. The type I receptor recruits a receptor regulated SMAD (R-SMAD) which it phosphorylates. The RSMAD then translocates to the nucleus where it functions as a transcription factor.
Alternate names: ACRV1A, ACVRLK2, ALK2, Activin receptor type IA, Activin receptor-like kinase 2, SKR1, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I
Gene ID 90
NCBI Accession 9606
UniProt Q04771
Application Notes Peptide ELISA: 1/128000. Western Blot: 0.3 - 1 µg/ml. Immunohistochemistry on paraffin sections: 4 - 6 µg/ml.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Activin Receptor Type 1 (ACRV1) (Internal Region) antibody anti-Activin Receptor Type 1 (ACRV1) (Internal Region) antibody
anti-Activin Receptor Type 1 (ACRV1) (Internal Region) antibody (2) anti-Activin Receptor Type 1 (ACRV1) (Internal Region) antibody (Image 2)
Background publications Shore, Xu, Feldman et al.: "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva." in: Nature genetics, Vol. 38, Issue 5, pp. 525-7, 2006 (PubMed).

Hosts (11), (2), (1)
Reactivities (12), (10), (4), (1), (1)
Applications (13), (10), (7), (1)
Epitopes (3), (3), (1), (1), (1), (1)
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