Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term), (Internal Region) antibody

Details for Product No. ABIN375025
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Antigen
Synonyms IRAK3, si:dkey-150i15.2, ASRT5, IRAKM, IrakM, 4833428C18Rik, AI563835, IRAK-M
Epitope
C-Term, Internal Region
(37), (8), (7), (5), (5), (5), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus)
(72), (30), (19), (1)
Host
Goat
(73), (9), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(87), (49), (22), (16), (14), (8), (5), (5), (4), (3), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN375025
357.50 $
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Immunogen Peptide with sequence C-GHSYGSKPMEKR, from the internal region (near the CTerminus) of the protein sequence
Specificity This antibody recognizes IRAK3 (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Mouse, Rat.
Purification Affinity chromatography
Alternative Name IRAK3
Background Reduced expression of IRAK-1 and increased expression of IRAK-M after CpG DNA pretreatment resulted in the hyporesponsiveness of macrophages that leads to the protection of mice from hepatic injury and death caused by CpG DNA/D-GalN. Endotoxin tolerance was significantly reduced in macrophages from IRAK-M knockout mice. IRAK-M regulates TLR signaling and innate immune homeostasis. induction of IRAK-M and inhibition of kinase activity of IRAK-1 are crucial to PGN-induced tolerance in macrophages. IRAK-M is a key regulator of the bone loss that is due to osteoclastic resorption of bone. IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages in the presence of Mycobacterium tuberculosis lipoarabinomannan. These findings indicate that IRAK-M selectively attenuates p38 activation and inhibits innate immunity through stabilizing MKP-1. IRAK-M is directly involved in the regulation of both innate and adaptive immune signaling processes, and deletion of IRAK-M enhances host anti-tumor immune response.Synonyms: IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3
Gene ID 11213
NCBI Accession NP_001135995
UniProt Q9Y616
Application Notes Peptide ELISA: 1/64000. Western Blot: 0.05 - 0.2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term), (Internal Region) antibody anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term), (Internal Region) antibody
Background publications Balaci, Spada, Olla et al.: "IRAK-M is involved in the pathogenesis of early-onset persistent asthma. ..." in: American journal of human genetics, Vol. 80, Issue 6, pp. 1103-14, 2007 (PubMed).

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