EPH Receptor B4 (EPHB4) antibody

Details for Product No. ABIN387814
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Antigen
Synonyms HTK, MYK1, TYRO11, AI042935, Htk, MDK2, Myk1, Tyro11, htk, myk1, ephB4a, tyro11, ephb4b, MGC130997
Reactivity
Human
(79), (32), (16), (12), (12), (12), (12), (1)
Host
Mouse
(39), (38), (7), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(69), (48), (14), (13), (12), (10), (7), (2), (2), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN387814
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen EPHB4 recombinant protein is used to produce this monoclonal antibody.
Clone 67CT23-5-8
Isotype IgG1 kappa
Specificity EPHB4 recombinant protein is used to produce this monoclonal antibody.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name EPHB4
Background Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.
Synonyms: Ephrin type-B receptor 4 , Tyrosine-protein kinase receptor HTK
Molecular Weight 108269 DA
Gene ID 2050
UniProt P54760
Research Area Phospho-specific antibodies, Stem Cells, Protein Modifications, Neurology, Cell Structure
Application Notes WB = 1:200-2000
Restrictions For Research Use only
Format Liquid
Concentration 0.3 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-EPH Receptor B4 (EPHB4) antibody Western blot analysis of anti-EPHB4 Monoclonal Antibody (ABIN387814) by EPHB4 recombinant protein(Fragment). EPHB4 protein (arrow) was detected using the purified Mab.
Background publications Pennisi, Ling, Li et al.: "The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth." in: Blood, Vol. 114, Issue 9, pp. 1803-12, 2009 (PubMed).

Kwan Tat, Pelletier, Amiable et al.: "Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes." in: Arthritis research & therapy, Vol. 11, Issue 4, pp. R119, 2009 (PubMed).

Suzuki, Abe, Imagama et al.: "BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4." in: European journal of haematology, Vol. 84, Issue 3, pp. 229-38, 2010 (PubMed).

Weinsheimer, Kim, Pawlikowska et al.: "EPHB4 gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations." in: Circulation. Cardiovascular genetics, Vol. 2, Issue 5, pp. 476-82, 2009 (PubMed).

Kuang, Bai, Fang et al.: "Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia." in: Blood, Vol. 115, Issue 12, pp. 2412-9, 2010 (PubMed).

Hosts (39), (38), (7), (2)
Reactivities (79), (32), (16), (12), (12), (12), (12), (1)
Applications (69), (48), (14), (13), (12), (10), (7), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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