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Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term) antibody

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Synonyms kmt1a, suv39h, H3-K9-HMTase 1, KMT1A, MG44, SUV39H, AI852103, AL022883, DXHXS7466e, mIS6, RGD1565028, fe02c04, suv39h1, wu:fe02c04, zgc:101027
(48), (15), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(90), (32), (20), (2), (2), (1), (1)
(71), (20)
Clonality (Clone)
Polyclonal ()
(6), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(72), (46), (16), (11), (11), (7), (4), (2), (2), (2)
Pubmed 6 references available
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Quantity 400 μL
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Availability Will be delivered in 2 to 4 Business Days
Immunogen Purified recombinant GST fusion protein encoding N-terminal of human SUV39H1.
Clone RB2153
Isotype Ig
Specificity Purified recombinant GST fusion protein encoding N-terminal of human SUV39H1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SUV39H1 (SUV39H1 Antibody Abstract)
Background Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
Synonyms: suppressor of variegation 3-9 homolog 1, Histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, Su(var)3-9 homolog 1, KMT1A
Molecular Weight 47907 DA
Gene ID 6839
NCBI Accession NP_003164
Research Area Signaling, Protein Modifications, Cancer, Chromatin, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term) antibody (ABIN387991) SUV39H1 (ABIN387991) western blot analysis in MDA-MB435 cell line lysates (35 µg/lane...
Product cited in: Benlhabib, Mendelson: "Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia." in: Molecular and cellular biology, Vol. 31, Issue 10, pp. 1949-58, 2011 (PubMed).

Background publications Macaluso, Cinti, Russo et al.: "pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer." in: Oncogene, Vol. 22, Issue 23, pp. 3511-7, 2003 (PubMed).

Fujita, Watanabe, Ichimura et al.: "Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 24132-8, 2003 (PubMed).

Schotta, Ebert, Krauss et al.: "Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing." in: The EMBO journal, Vol. 21, Issue 5, pp. 1121-31, 2002 (PubMed).

Vaute, Nicolas, Vandel et al.: "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases." in: Nucleic acids research, Vol. 30, Issue 2, pp. 475-81, 2002 (PubMed).

Rea, Eisenhaber, OCarroll et al.: "Regulation of chromatin structure by site-specific histone H3 methyltransferases." in: Nature, Vol. 406, Issue 6796, pp. 593-9, 2000 (PubMed).

Catalog No. ABIN387991
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