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Details for Product No. ABIN387995

Lysine (K)-Specific Demethylase 3A (KDM3A) (N-Term), (AA 50-79) antibody

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Synonyms JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA, TGSA, Tsga, Jmjd1, KDM2A, JHDM2a, Jmjd1a, mKIAA0742, 1700105C21Rik, C230043E16Rik, tsga, jmjd1, jhdm2a, jhmd2a, jmjd1a, KDM3A
»Alternatives N-Term, AA 50-79
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN387995
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This JHDM2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 AA from the N-terminal region of human JHDM2a.
Clone RB14307
Isotype Ig
Specificity This JHDM2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57~86 amino acids from the N-terminal region of human JHDM2A.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name JHDM2a
Background JHDM2a is a zinc finger protein that contains a jumonji domain. It is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. This protein preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. It is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation.
Synonyms: TSGA, JMJD1, KDM3A, JHDM2A, JHMD2A, KIAA0742, DKFZp686A24246, DKFZp686P07111, JMJD1A
Molecular Weight 147211 DA
Gene ID 55818
UniProt NP_060903
Research Area Protein Modifications
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Yamane, Toumazou, Tsukada et al.: "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor." in: Cell, Vol. 125, Issue 3, pp. 483-95, 2006 (PubMed).

Wellmann, Bettkober, Zelmer et al.: "Hypoxia upregulates the histone demethylase JMJD1A via HIF-1." in: Biochemical and biophysical research communications, Vol. 372, Issue 4, pp. 892-7, 2008 (PubMed).

Alternatives for antigen "Lysine (K)-Specific Demethylase 3A (KDM3A)", type "Antibodies"
Hosts (29), (15)
Reactivities (44), (19), (12), (1), (1), (1), (1), (1)
Applications (43), (25), (22), (10), (10), (9), (2)
Conjugates (1), (1), (1), (1), (1)
Epitopes (9), (6), (5), (4), (2), (2), (1), (1), (1)