Lysine (K)-Specific Demethylase 3A (KDM3A) (N-Term), (AA 50-79) antibody

Details for Product No. ABIN387995
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA, TGSA, Tsga, Jmjd1, KDM2A, JHDM2a, Jmjd1a, mKIAA0742, 1700105C21Rik, C230043E16Rik, tsga, jmjd1, jhdm2a, jhmd2a, jmjd1a, KDM3A
Epitope
N-Term, AA 50-79
(8), (5), (4), (3), (2), (1)
Reactivity
Human, Mouse (Murine)
(43), (18), (12), (1), (1), (1), (1), (1)
Host
Rabbit
(26), (17)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(43), (27), (21), (13), (10), (10), (2)
Pubmed 2 references available
Catalog no. ABIN387995
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Discontinued
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This JHDM2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 AA from the N-terminal region of human JHDM2a.
Clone RB14307
Isotype Ig
Specificity This JHDM2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57~86 amino acids from the N-terminal region of human JHDM2A.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name JHDM2a
Background JHDM2a is a zinc finger protein that contains a jumonji domain. It is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. This protein preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. It is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation.
Synonyms: TSGA, JMJD1, KDM3A, JHDM2A, JHMD2A, KIAA0742, DKFZp686A24246, DKFZp686P07111, JMJD1A
Molecular Weight 147211 DA
Gene ID 55818
UniProt NP_060903
Research Area Protein Modifications
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Lysine (K)-Specific Demethylase 3A (KDM3A) (N-Term), (AA 50-79) antibody JHDM2a Antibody (N-term) (ABIN387995) western blot analysis in mouse testis tissue lysates (35 µg/lane).This demonstrates the JHDM2a antibody detected the JHDM2a protein (arrow).
anti-Lysine (K)-Specific Demethylase 3A (KDM3A) (N-Term), (AA 50-79) antibody (2) JHDM2a Antibody (N-term) (ABIN387995)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Yamane, Toumazou, Tsukada et al.: "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor." in: Cell, Vol. 125, Issue 3, pp. 483-95, 2006 (PubMed).

Wellmann, Bettkober, Zelmer et al.: "Hypoxia upregulates the histone demethylase JMJD1A via HIF-1." in: Biochemical and biophysical research communications, Vol. 372, Issue 4, pp. 892-7, 2008 (PubMed).

Hosts (26), (17)
Reactivities (43), (18), (12), (1), (1), (1), (1), (1)
Applications (43), (27), (21), (13), (10), (10), (2)
Conjugates (1), (1), (1), (1), (1)
Epitopes (8), (5), (4), (3), (2), (1)
back to top