Lysine (K)-Specific Demethylase 3A (KDM3A) (N-Term), (AA 50-79) antibody

Details for Product No. ABIN387995
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Antigen
Epitope
N-Term, AA 50-79
(8), (7), (6), (5), (4), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(49), (18), (12), (1), (1), (1), (1), (1)
Host
Rabbit
(32), (17)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(48), (31), (25), (13), (10), (10), (4)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN387995
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Immunogen This JHDM2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 AA from the N-terminal region of human JHDM2a.
Clone RB14307
Isotype Ig
Specificity This JHDM2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57~86 amino acids from the N-terminal region of human JHDM2A.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name JHDM2a
Background JHDM2a is a zinc finger protein that contains a jumonji domain. It is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. This protein preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. It is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation.
Synonyms: TSGA, JMJD1, KDM3A, JHDM2A, JHMD2A, KIAA0742, DKFZp686A24246, DKFZp686P07111, JMJD1A
Molecular Weight 147211 DA
Gene ID 55818
NCBI Accession NP_060903
Research Area Protein Modifications
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Lysine (K)-Specific Demethylase 3A (KDM3A) (N-Term), (AA 50-79) antibody JHDM2a Antibody (N-term) (ABIN387995) western blot analysis in mouse testis tissue lysates (35 µg/lane).This demonstrates the JHDM2a antibody detected the JHDM2a protein (arrow).
anti-Lysine (K)-Specific Demethylase 3A (KDM3A) (N-Term), (AA 50-79) antibody (2) JHDM2a Antibody (N-term) (ABIN387995)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Yamane, Toumazou, Tsukada et al.: "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor." in: Cell, Vol. 125, Issue 3, pp. 483-95, 2006 (PubMed).

Wellmann, Bettkober, Zelmer et al.: "Hypoxia upregulates the histone demethylase JMJD1A via HIF-1." in: Biochemical and biophysical research communications, Vol. 372, Issue 4, pp. 892-7, 2008 (PubMed).

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