SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term), (AA 1081-1112) antibody

Details for Product No. ABIN388052
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Antigen
Synonyms SSP1, SUSP1
Epitope
C-Term, AA 1081-1112
(9), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(37), (4), (2), (1)
Host
Rabbit
(26), (10), (4)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(25), (21), (11), (8), (1)
Pubmed 3 references available
Catalog no. ABIN388052
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This SENP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1081-1112 AA from the C-terminal region of human SENP6.
Clone RB0664
Isotype Ig
Specificity This SENP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1083~1112 amino acids from the C-terminal region of human SENP6.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SENP6
Background SENP6 (SUSP1) is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. This protein does not seem to be involved in the processing of full-length SUMO proteins to their mature conjugatable forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.
Synonyms: Sentrin-specific protease 6, Sentrin/SUMO-specific protease SENP6, SUMO-1-specific protease 1, SENP6, KIAA0797, SSP1, SUSP1
Molecular Weight 126144 DA
Gene ID 26054
UniProt Q9GZR1
Research Area Apoptosis/Necrosis, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term), (AA 1081-1112) antibody Western blot analysis of SENP6 polyclonal antibody (ABIN388052) in HL60 cell lysate. SENP6 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term), (AA 1081-1112) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Kim, Baek, Jeon et al.: "A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs." in: The Journal of biological chemistry, Vol. 275, Issue 19, pp. 14102-6, 2000 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Hosts (26), (10), (4)
Reactivities (37), (4), (2), (1)
Applications (25), (21), (11), (8), (1)
Epitopes (9), (3), (2), (2), (2), (1), (1), (1), (1)
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