SENP6 Products
(SUMO1/sentrin Specific Protease 6 (SENP6))
Categories
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1\; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA\; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009].
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Featured SENP6 Categories
SENP6 Antibodies
High quality antibodies with extensive validation data.
SENP6 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SENP6 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC (p)
Validations
- (3)
- (4)
Cat. No.
ABIN565219
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
- (3)
Cat. No.
ABIN388052
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF, FACS
Validations
- (3)
Cat. No.
ABIN334488
Quantity
100 μg
Datasheet
Datasheet
Recommended SENP6 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319510
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3095426
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3135755
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SENP6 products
: "ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability." in: Molecular cell, Vol. 70, Issue 1, pp. 165-174.e6, (2019) (PubMed).: "Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6." in: PLoS pathogens, Vol. 9, Issue 6, pp. e1003480, (2013) (PubMed).
: "SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage." in: The EMBO journal, Vol. 31, Issue 23, pp. 4441-52, (2012) (PubMed).
: "Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex." in: Molecular cell, Vol. 39, Issue 3, pp. 333-45, (2010) (PubMed).
: "SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 12906-15, (2010) (PubMed).
: "Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1." in: The Journal of biological chemistry, Vol. 281, Issue 41, pp. 30669-77, (2006) (PubMed).
: "Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 44, pp. 16272-7, (2006) (PubMed).
: "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 692-703, (2003) (PubMed).
: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
Synonyms and alternative names related to SENP6
SUMO1/sentrin specific peptidase 6 (SENP6), SUMO/sentrin specific peptidase 6 (Senp6), SUMO1/sentrin specific peptidase 6 (Senp6), SUMO1/sentrin specific peptidase 6a (senp6a), 2810017C20Rik, E130319N12Rik, fc83h02, im:7148342, mKIAA0797, SSP1, SUSP1, Susp1, wu:fc83h02, zgc:171230Protein level used designations for SENP6
- 2810017C20Rik
- SUMO-1-specific protease 1
- SUMO1/sentrin specific protease 6
- sentrin-specific protease 6
- sentrin/SUMO-specific protease SENP6
- SUMO1/sentrin specific peptidase 6
- SUMO/sentrin specific protease 6
- SUMO/sentrin specific peptidase 6
- Sumo1/sentrin/SMT3 specific peptidase 6
- Sentrin-specific protease 6-like protein
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