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Details for Product No. ABIN388117

BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) (AA 152-187), (N-Term), (BH3 Domain) antibody

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Antigen
Synonyms NIP3, Nip3
Epitope
»Alternatives AA 152-187, N-Term, BH3 Domain
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN388117
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This BNIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-187 AA from human BNIP3.
Clone RB3385
Isotype Ig
Specificity This BNIP3 Antibody antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region (BH3 domain) of human NIP3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name BNIP3 (NIP3)
Background NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.
Synonyms: BCL2/adenovirus E1B 19-kDa protein-interacting protein 3, BNIP3
Molecular Weight 21541 Da
Gene ID 664
UniProt Q12983
Research Area Apoptosis/Necrosis, Cell Structure, Cancer
Application Notes Recommend dilutions: IF : 1:50-100,WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Yasuda, Theodorakis, Subramanian et al.: "Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12415-21, 1998 (PubMed).

Kothari, Cizeau, McMillan-Ward et al.: "BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF." in: Oncogene, Vol. 22, Issue 30, pp. 4734-44, 2003 (PubMed).

Alternatives for antigen "BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3)", type "Antibodies"
Hosts (66), (4), (1)
Reactivities (67), (32), (27), (25), (24), (14), (12), (2), (1)
Applications (46), (20), (17), (16), (13), (10), (8), (7), (4), (1), (1), (1)
Conjugates (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (12), (7), (6), (5), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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