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BNIP3 Products

(BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3))

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This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2. [provided by RefSeq, Mar 2011].

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Featured BNIP3 Categories

BNIP3 Antibodies

High quality antibodies with extensive validation data.

BNIP3 ELISA Kits

Reliable ELISA kits for a wide range of species.

BNIP3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended BNIP3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (7)
Cat. No. ABIN5542288
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application IF, IHC, ELISA, WB
Validations
  • (6)
Cat. No. ABIN3030151
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (5)
Cat. No. ABIN5542289
Quantity 0.1 mg
Datasheet Datasheet

Recommended BNIP3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954066
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5690831
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1123395
Quantity 96 tests
Datasheet Datasheet

Recommended BNIP3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3114555
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3131839
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7121989
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our BNIP3 products

Heng, Rattner, Stein-OBrien, Winer, Jones, Vernon, Goff, Nathans: "Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 18, pp. 9103-9114, (2019) (PubMed).

Chen, Li, Li, Feng, Liu, Wang, Dai, Xia, Lu, Zhou, Guo: "15-Deoxy-Δ12,14-prostaglandin J2 alleviates hepatic ischemia-reperfusion injury in mice via inducing antioxidant response and inhibiting apoptosis and autophagy." in: Acta pharmacologica Sinica, Vol. 38, Issue 5, pp. 672-687, (2018) (PubMed).

Zhang, Liu, Xue, Ma, Liu, Li, Li, Liu: "Endothelial Monocyte-Activating Polypeptide-II Induces BNIP3-Mediated Mitophagy to Enhance Temozolomide Cytotoxicity of Glioma Stem Cells via Down-Regulating MiR-24-3p." in: Frontiers in molecular neuroscience, Vol. 11, pp. 92, (2018) (PubMed).

Du, Li, Xu, Zhou, Zhang, Wang: "MicroRNA-145 induces apoptosis of glioma cells by targeting BNIP3 and Notch signaling." in: Oncotarget, Vol. 8, Issue 37, pp. 61510-61527, (2017) (PubMed).

Karpathiou, Sivridis, Koukourakis, Mikroulis, Bouros, Froudarakis, Bougioukas, Maltezos, Giatromanolaki: "Autophagy and Bcl-2/BNIP3 death regulatory pathway in non-small cell lung carcinomas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 121, Issue 7, pp. 592-604, (2013) (PubMed).

Morten, Badder, Knowles: "Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts." in: The Journal of pathology, Vol. 229, Issue 5, pp. 755-64, (2013) (PubMed).

Wojtkowiak, Rothberg, Kumar, Schramm, Haller, Proemsey, Lloyd, Sloane, Gillies: "Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments." in: Cancer research, Vol. 72, Issue 16, pp. 3938-47, (2012) (PubMed).

Qi, Tian, Liu, Han, Graham, Simon, Penninger, Carmeliet, Li: "Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis." in: The Journal of cell biology, Vol. 198, Issue 1, pp. 103-14, (2012) (PubMed).

Landes, Emorine, Courilleau, Rojo, Belenguer, Arnauné-Pelloquin: "The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms." in: EMBO reports, Vol. 11, Issue 6, pp. 459-65, (2010) (PubMed).

Metukuri, Beer-Stolz, Namas, Dhupar, Torres, Loughran, Jefferson, Tsung, Billiar, Vodovotz, Zamora: "Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 296, Issue 3, pp. G499-509, (2009) (PubMed).

Synonyms and alternative names related to BNIP3

BCL2 interacting protein 3 (BNIP3), BCL2/adenovirus E1B interacting protein 3 (Bnip3), BCL2 interacting protein 3 (Bnip3), NIP3, Nip3

Protein level used designations for BNIP3

  • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
  • BCL2/adenovirus E1B 19kD-interacting protein 3
  • BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3
  • BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3
  • BCL2/adenovirus E1B interacting protein 1, NIP3
  • BCL2/adenovirus E1B 19 kDa-interacting protein 3
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