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HtrA Serine Peptidase 1 (HTRA1) (AA 381-412), (C-Term) antibody

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Synonyms htra1, zgc:92029, zgc:172061, l56, htra, Xhtra1, prss11, MGC145723, ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11, AI429470, HTRA, Prss11, RSPP11, HTRA1
AA 381-412, C-Term
(21), (19), (9), (8), (4), (4), (2), (1), (1)
(64), (10), (6)
(63), (1)
Clonality (Clone)
Polyclonal ()
(7), (5), (4), (4), (4), (4)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(57), (34), (33), (8), (6), (3), (2), (2), (2)
Pubmed 5 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This HtrA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-412 AA from the C-terminal region of human HtrA1.
Clone RB02327
Isotype Ig
Predicted Reactivity Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name HtrA1 (HTRA1 Antibody Abstract)
Background HtrA1 is a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.

Synonyms: Serine protease HTRA1, L56
Molecular Weight 51286 Da
Gene ID 5654
UniProt Q92743
Research Area Apoptosis/Necrosis, Cancer, Cell Structure
Application Notes Suggested dilutions:
WB = 1:1000, IHC (p) = 1:50-100
Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1.55 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-HtrA Serine Peptidase 1 (HTRA1) (AA 381-412), (C-Term) antibody (ABIN388128) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-HtrA Serine Peptidase 1 (HTRA1) (AA 381-412), (C-Term) antibody (ABIN388128) HtrA1-K396 (ABIN388128) western blot analysis in Hela cell line lysates (35 µg/lane)....
Product cited in: Chamberland, Wang, Jones et al.: "Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27352-9, 2009 (PubMed).

Background publications Howes, Lerch, Greenhalf et al.: "Clinical and genetic characteristics of hereditary pancreatitis in Europe." in: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Vol. 2, Issue 3, pp. 252-61, 2004 (PubMed).

Chien, Staub, Hu et al.: "A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer." in: Oncogene, Vol. 23, Issue 8, pp. 1636-44, 2004 (PubMed).

Hu, Carozza, Klein et al.: "Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage." in: The Journal of biological chemistry, Vol. 273, Issue 51, pp. 34406-12, 1999 (PubMed).

Zumbrunn, Trueb: "Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2." in: Genomics, Vol. 45, Issue 2, pp. 461-2, 1998 (PubMed).

Catalog No. ABIN388128
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