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HTRA1 Products

(HtrA Serine Peptidase 1 (HTRA1))
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008].

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Featured HTRA1 Categories

HTRA1 Antibodies

High quality antibodies with extensive validation data.

HTRA1 ELISA Kits

Reliable ELISA kits for a wide range of species.

HTRA1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HTRA1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (3)
Cat. No. ABIN7168916
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN7254340
Quantity 200 μL
Datasheet Datasheet
Reactivity Cow, Human, Mouse, Pig, Rat
Application IHC, WB
Validations
  • (2)
Cat. No. ABIN2789539
Quantity 100 μL
Datasheet Datasheet

Recommended HTRA1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6962019
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6960711
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
Cat. No. ABIN4370341
Quantity 96 tests
Datasheet Datasheet

Recommended HTRA1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN7041634
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3092982
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3137441
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our HTRA1 products

Giannubilo, Licini, Picchiassi, Tarquini, Coata, Fantone, Tossetta, Ciavattini, Castellucci, Giardina, Gesuita, Marzioni: "First trimester HtrA1 maternal plasma level and spontaneous preterm birth." in: The journal of maternal-fetal & neonatal medicine, pp. 1-5, (2020) (PubMed).

Beguier, Housset, Roubeix, Augustin, Zagar, Nous, Mathis, Eandi, Benchaboune, Drame-Maigné, Carpentier, Chardonnet, Touhami, Blot, Conart, Charles-Messance, Potey, Girmens, Paques, Blond, Leveillard et al.: "The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination. ..." in: Immunity, Vol. 53, Issue 2, pp. 429-441.e8, (2020) (PubMed).

Lorenzi, Lorenzi, Marzetti, Landi, Vetrano, Settanni, Antocicco, Bonassi, Valdiglesias, Bernabei, Onder: "Association of frailty with the serine protease HtrA1 in older adults." in: Experimental gerontology, Vol. 81, pp. 8-12, (2016) (PubMed).

Frochaux, Hildebrand, Talke, Linscheid, Schlüter: "Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue." in: PLoS ONE, Vol. 9, Issue 10, pp. e109483, (2014) (PubMed).

Marzioni, Lorenzi, Altobelli, Giannubilo, Paolinelli, Tersigni, Crescimanno, Monsurrò, Tranquilli, Di Simone, Castellucci: "Alterations of maternal plasma HTRA1 level in preeclampsia complicated by IUGR." in: Placenta, Vol. 33, Issue 12, pp. 1036-8, (2012) (PubMed).

Inagaki, Nishizawa, Ota, Suzuki, Inuzuka, Miyamura, Sekiya, Kurahashi, Udagawa: "Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia." in: Placenta, Vol. 33, Issue 11, pp. 919-26, (2012) (PubMed).

Wang, Eckert, Zomorrodi, Xin, Pan, Shearer, Weisz, Maranus, Clawson: "Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways." in: PLoS ONE, Vol. 7, Issue 6, pp. e39446, (2012) (PubMed).

Shiga, Nozaki, Yokoseki, Nihonmatsu, Kawata, Kato, Koyama, Arima, Ikeda, Katada, Toyoshima, Takahashi, Tanaka, Nakano, Ikeuchi, Nishizawa, Onodera: "Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1." in: Human molecular genetics, Vol. 20, Issue 9, pp. 1800-10, (2011) (PubMed).

Chamberland, Wang, Jones, Collins-Racie, LaVallie, Huang, Liu, Morris, Flannery, Yang: "Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27352-9, (2009) (PubMed).

Clawson, Bui, Xin, Wang, Pan: "Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins." in: Journal of cellular biochemistry, Vol. 105, Issue 1, pp. 81-8, (2008) (PubMed).

Synonyms and alternative names related to HTRA1

HtrA serine peptidase 1a (htra1a), HtrA serine peptidase 1 (HTRA1), HtrA serine peptidase 1b (htra1b), HtrA serine peptidase 1 (htra1), Serine protease HTRA1 (htra1), HtrA serine peptidase 1 (Htra1), HtrA serine peptidase 1 S homeolog (htra1.S), AI429470, ARMD7, CARASIL, htra, HtrA, HTRA, htra1, HTRA1, l56, L56, MGC145723, ORF480, prss11, PRSS11, Prss11, RSPP11, Xhtra1, zgc:92029, zgc:172061

Protein level used designations for HTRA1

  • HtrA serine peptidase 1
  • high-temperature requirement A serine peptidase 1A
  • serine protease 11
  • serine protease HTRA1A
  • high-temperature requirement A serine peptidase 1B
  • serine protease HTRA1B
  • high temperature required A1
  • Serine protease HTRA1
  • IGFBP5-protease
  • high-temperature requirement A serine peptidase 1
  • protease, serine, 11 (IGF binding)
  • serine protease HTRA1
  • insulin-like growth factor binding protein 5 protease
  • protease, serine, 11 (Igf binding)
  • IGF binding
  • protease, serine, 11
  • protease serine 11
  • High-temperature requirement A serine peptidase 1
  • Serine protease 11
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