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Details for Product No. ABIN388128

HtrA Serine Peptidase 1 (HTRA1) (C-Term), (AA 381-412) antibody

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Synonyms ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11, HTRA, Prss11, RSPP11, AI429470, Xhtra1, htra, prss11, htra1, zgc:92029, zgc:172061, l56, MGC145723
»Alternatives C-Term, AA 381-412
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 5 references available
Catalog no. ABIN388128
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This HtrA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-412 AA from the C-terminal region of human HtrA1.
Clone RB02327
Isotype Ig
Specificity This HtrA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389~419 amino acids from the C-terminal region of human HtrA1.
Predicted Reactivity Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name HtrA1
Background HtrA1 is a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.
Synonyms: Serine protease HTRA1, L56
Molecular Weight 51286 DA
Gene ID 5654
UniProt Q92743
Research Area Apoptosis/Necrosis, Cancer, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.55 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Zumbrunn, Trueb: "Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2." in: Genomics, Vol. 45, Issue 2, pp. 461-2, 1998 (PubMed).

Hu, Carozza, Klein et al.: "Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage." in: The Journal of biological chemistry, Vol. 273, Issue 51, pp. 34406-12, 1999 (PubMed).

Chien, Staub, Hu et al.: "A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer." in: Oncogene, Vol. 23, Issue 8, pp. 1636-44, 2004 (PubMed).

Howes, Lerch, Greenhalf et al.: "Clinical and genetic characteristics of hereditary pancreatitis in Europe." in: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Vol. 2, Issue 3, pp. 252-61, 2004 (PubMed).

Chamberland, Wang, Jones et al.: "Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27352-9, 2009 (PubMed).

Alternatives for antigen "HtrA Serine Peptidase 1 (HTRA1)", type "Antibodies"
Hosts (21)
Reactivities (21), (8), (4), (2), (2), (1), (1)
Applications (21), (10), (6), (5), (5), (4), (2)
Conjugates (2)
Epitopes (6), (3), (3), (2), (1), (1)