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TPX2, Microtubule-Associated Protein Homolog (Xenopus Laevis) (TPX2) (AA 350-382) antibody

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Synonyms DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb), 2610005B21Rik, DIL2, REPP86, p100
AA 350-382
(1), (1), (1)
(10), (6)
(6), (4)
Clonality (Clone)
Polyclonal ()
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(7), (2), (1)
Pubmed 3 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This P100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-382 AA from human P100.
Clone RB0559
Isotype Ig
Specificity This P100 antibody is generated from rabbits immunized with mixture of 3 KLH conjugated synthetic peptides between 358~388 amino acids from C-terminal region with phenylalanine at position 624, C-terminal region with serine at position 729, and center region of human NRG4.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name P100 (TPX2 Antibody Abstract)
Background The nuclear protein p100 is a proliferation-associated protein whose expression is restricted to cell cycle phases S, G2, and M. Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis. During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. The full-length cDNA encodes a 747-amino acid protein with a putative ATP/GTP-binding site motif. RT-PCR analysis demonstrated strong expression of in lung carcinoma cell lines but not in normal lung tissues. Expression was also found in adult placenta, skeletal muscle, thymus, testis, and small intestine and in fetal brain, liver, and kidney. P100 is also correlated to cancer prognosis.
Synonyms: TPX2, C20orf1, C20orf2, DIL2, HCA519, p100, Protein FLS353, Hepatocellular carcinoma-associated antigen 519, Targeting protein for Xklp2, Restricted expression proliferation associated protein 100, Differentially expressed in cancerous and noncancerous lu
Molecular Weight 85653 DA
Gene ID 22974
UniProt Q9ULW0
Research Area Cancer, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.21 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TPX2, Microtubule-Associated Protein Homolog (Xenopus Laevis) (TPX2) (AA 350-382) antibody (ABIN388785) The anti-p100 Pab (ABIN388785) is used in Western blot to detect p100 in placenta lys...
Immunohistochemistry (IHC) image for anti-TPX2, Microtubule-Associated Protein Homolog (Xenopus Laevis) (TPX2) (AA 350-382) antibody (ABIN388785) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Heidebrecht, Adam-Klages, Szczepanowski et al.: "repp86: A human protein associated in the progression of mitosis." in: Molecular cancer research : MCR, Vol. 1, Issue 4, pp. 271-9, 2003 (PubMed).

Kufer, Silljé, Körner et al.: "Human TPX2 is required for targeting Aurora-A kinase to the spindle." in: The Journal of cell biology, Vol. 158, Issue 4, pp. 617-23, 2002 (PubMed).

Catalog No. ABIN388785
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