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SLUG (N-Term), (AA 1-30) antibody

Details for Product No. ABIN388808
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Antigen
Epitope
N-Term, AA 1-30
(5), (4), (4), (2), (1)
Reactivity
Human
(16), (15), (3)
Host
Rabbit
(17)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB)
(17), (14), (5)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN388808
291.50 $
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Immunogen This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human SLUG.
Clone RB15389
Isotype Ig
Specificity This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2~32 amino acids from the N-terminal region of human SLUG.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Background SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. This protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in the gene encoding SLUG may be associated with sporadic cases of neural tube defects.
Synonyms: Zinc finger protein SLUG, Neural crest transcription factor Slug, Snail homolog 2,SNAI2
UniProt O43623
Research Area Apoptosis/Necrosis, Stem Cells, Transcription Factors, Signaling
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
Expiry Date 6 months
Supplier Images
anti-SLUG (N-Term), (AA 1-30) antibody (LEFT)Western blot analysis of anti-SLUG Antibody (N-term K9) Pab (ABIN388808) in A2058 cell line lysates (35 µg/lane). SLUG(arrow) was detected using the purified polyclonal antibody. (RIGHT)Western blot analysis of SLUG Antibody (N-term K9) (ABIN388808) in HCSMC cell line lysates (35 µg/lane).SLUG (arrow) was detected using the purified polyclonal antibody.
Background publications Hemavathy, Guru, Harris et al.: "Human Slug is a repressor that localizes to sites of active transcription." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 5087-95, 2000 (PubMed).

Hajra, Chen, Fearon: "The SLUG zinc-finger protein represses E-cadherin in breast cancer." in: Cancer research, Vol. 62, Issue 6, pp. 1613-8, 2002 (PubMed).

Sánchez-Martín, Rodríguez-García, Pérez-Losada et al.: "SLUG (SNAI2) deletions in patients with Waardenburg disease." in: Human molecular genetics, Vol. 11, Issue 25, pp. 3231-6, 2002 (PubMed).

Validation Images
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