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Details for Product No. ABIN388808

SLUG (N-Term), (AA 1-30) antibody

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Antigen
Epitope
»Alternatives N-Term, AA 1-30
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN388808
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human SLUG.
Clone RB15389
Isotype Ig
Specificity This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2~32 amino acids from the N-terminal region of human SLUG.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Background SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. This protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in the gene encoding SLUG may be associated with sporadic cases of neural tube defects.
Synonyms: Zinc finger protein SLUG, Neural crest transcription factor Slug, Snail homolog 2,SNAI2
UniProt O43623
Research Area Apoptosis/Necrosis, Stem Cells, Transcription Factors, Signaling
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
Expiry Date 6 months
Background publications Hemavathy, Guru, Harris et al.: "Human Slug is a repressor that localizes to sites of active transcription." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 5087-95, 2000 (PubMed).

Hajra, Chen, Fearon: "The SLUG zinc-finger protein represses E-cadherin in breast cancer." in: Cancer research, Vol. 62, Issue 6, pp. 1613-8, 2002 (PubMed).

Sánchez-Martín, Rodríguez-García, Pérez-Losada et al.: "SLUG (SNAI2) deletions in patients with Waardenburg disease." in: Human molecular genetics, Vol. 11, Issue 25, pp. 3231-6, 2002 (PubMed).

Alternatives for antigen "SLUG", type "Antibodies"
Hosts (15), (11)
Reactivities (24), (13), (3)
Applications (26), (12), (6), (6), (3)
Epitopes (5), (4), (4), (1)
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