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Details for Product No. ABIN388843

Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1) (C-Term), (AA 111-140) antibody

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Antigen
Synonyms SFT, UBCH5, UBC4/5, UBCH5A, E2(17)KB1, ube2d1, wu:fc16h06, zgc:73096, sft, ubch5, ubc4/5, ubch5a, e2(17)kb1
Epitope
»Alternatives C-Term, AA 111-140
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN388843
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This UBE2D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-140 AA from the C-terminal region of human UBE2D1.
Clone RB04139
Isotype Ig
Specificity This UBE2D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118~147 amino acids from the C-terminal region of human UBE2D1.
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name UBE2D1
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D1 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
Synonyms: Ubiquitin-conjugating enzyme E2-17 kDa 1, Ubiquitin-protein ligase, Ubiquitin carrier protein, E2(17)KB 1
Molecular Weight 16602 DA
Gene ID 7321
UniProt NP_003329
Research Area Ubiquitin-related antibodies, Protein Modifications, Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Jensen, Bates, Yang et al.: "Identification of a family of closely related human ubiquitin conjugating enzymes." in: The Journal of biological chemistry, Vol. 270, Issue 51, pp. 30408-14, 1996 (PubMed).

Kamura, Sato, Iwai et al.: "Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 19, pp. 10430-5, 2000 (PubMed).

Gehrke, Riedel, Herrmann et al.: "UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis." in: Blood, Vol. 101, Issue 8, pp. 3288-93, 2003 (PubMed).

Brès, Kiernan, Linares et al.: "A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter." in: Nature cell biology, Vol. 5, Issue 8, pp. 754-61, 2003 (PubMed).

Alternatives for antigen "Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1)", type "Antibodies"
Hosts (26), (4)
Reactivities (29), (18), (15), (13), (1), (1), (1), (1), (1)
Applications (21), (11), (10), (9), (6), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (1), (1), (1)
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