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UBE2D1 Products

(Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1))

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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].

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Featured UBE2D1 Categories

UBE2D1 Antibodies

High quality antibodies with extensive validation data.

UBE2D1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended UBE2D1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (1)
  • (4)
Cat. No. ABIN521211
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN7259985
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7174434
Quantity 100 μg
Datasheet Datasheet

Recommended UBE2D1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6951479
Quantity 96 tests
Datasheet Datasheet

Recommended UBE2D1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125608
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324340
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324342
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our UBE2D1 products

Lewis, Vyse, Shields, Boeltz, Gordon, Spector, Lehner, Walczak, Vyse: "UBE2L3 polymorphism amplifies NF-?B activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases." in: American journal of human genetics, Vol. 96, Issue 2, pp. 221-34, (2015) (PubMed).

Zhu, Du, Zhou, Roizman: "The stability of herpes simplex virus 1 ICP0 early after infection is defined by the RING finger and the UL13 protein kinase." in: Journal of virology, Vol. 88, Issue 10, pp. 5437-43, (2014) (PubMed).

Basic, Tadele, Elmabsout, Yao, Rahman, Sirsjö, Abdel-Halim: "Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 303, Issue 6, pp. L519-27, (2012) (PubMed).

Brès, Kiernan, Linares, Chable-Bessia, Plechakova, Tréand, Emiliani, Peloponese, Jeang, Coux, Scheffner, Benkirane: "A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter." in: Nature cell biology, Vol. 5, Issue 8, pp. 754-61, (2003) (PubMed).

Gehrke, Riedel, Herrmann, Hadaschik, Bents, Veltkamp, Stremmel: "UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis." in: Blood, Vol. 101, Issue 8, pp. 3288-93, (2003) (PubMed).

Kamura, Sato, Iwai, Czyzyk-Krzeska, Conaway, Conaway: "Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 19, pp. 10430-5, (2000) (PubMed).

Synonyms and alternative names related to UBE2D1

ubiquitin conjugating enzyme E2 D1 (UBE2D1), ubiquitin-conjugating enzyme E2D 1 (Ube2d1), ubiquitin-conjugating enzyme E2D 1b (ube2d1b), ubiquitin conjugating enzyme E2 D1 S homeolog (ube2d1.S), ubiquitin conjugating enzyme E2 D1 (ube2d1), ubiquitin conjugating enzyme E2 D1 (Ube2d1), E2(17)KB1, e2(17)kb1, SFT, sft, UBC4/5, ubc4/5, UBCH5, ubch5, UBCH5A, ubch5a, ube2d1, wu:fc16h06, zgc:73096

Protein level used designations for UBE2D1

  • UBC4/5 homolog
  • stimulator of Fe transport
  • ubiquitin carrier protein D1
  • ubiquitin-conjugating enzyme E2 D1
  • ubiquitin-conjugating enzyme E2(17)KB 1
  • ubiquitin-conjugating enzyme E2-17 kDa 1
  • ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
  • ubiquitin-protein ligase D1
  • E2(17)KB 1
  • ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog
  • ubiquitin-conjugating enzyme E2D 1
  • ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog)
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