Lethal Giant Larvae Homolog 1 (Drosophila) (LLGL1) (N-Term), (AA 172-205) antibody

Details for Product No. ABIN388988
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Antigen
Epitope
N-Term, AA 172-205
(7), (6), (6), (6), (2), (2)
Reactivity
Human
(27), (12), (12), (12), (12)
Host
Rabbit
(23), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(18), (12), (10), (3), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN388988
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Immunogen This LLGL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-205 AA from the N-terminal region of human LLGL1.
Clone RB7619
Isotype Ig
Specificity This LLGL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human LLGL1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name LLGL1
Background LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17.
Synonyms: Hugl protein, LLGL1, hugl,
Molecular Weight 114379 DA
Gene ID 3996
UniProt Q15334
Research Area Cancer, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Lethal Giant Larvae Homolog 1 (Drosophila) (LLGL1) (N-Term), (AA 172-205) antibody Western blot analysis of anti-hLLGL1 Pab (ABIN388988) in 293 cell line lysate. hLLGL1(arrow) was detected using the purified polyclonal antibody.
Background publications Katoh, Katoh: "Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico." in: International journal of oncology, Vol. 24, Issue 3, pp. 737-42, 2004 (PubMed).

Grifoni, Garoia, Schimanski et al.: "The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo." in: Oncogene, Vol. 23, Issue 53, pp. 8688-94, 2004 (PubMed).

Schimanski, Schmitz, Kashyap et al.: "Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer." in: Oncogene, Vol. 24, Issue 19, pp. 3100-9, 2005 (PubMed).

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