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Details for Product No. ABIN388988

Lethal Giant Larvae Homolog 1 (Drosophila) (LLGL1) (N-Term), (AA 172-205) antibody

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Antigen
Synonyms DLG4, HUGL, LLGL, HUGL1, HUGL-1, AI325176, Lgl1, Llglh, Mgl1, Rgl1, LLGL1
Epitope
»Alternatives N-Term, AA 172-205
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN388988
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This LLGL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-205 AA from the N-terminal region of human LLGL1.
Clone RB7619
Isotype Ig
Specificity This LLGL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human LLGL1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name LLGL1
Background LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17.
Synonyms: Hugl protein, LLGL1, hugl,
Molecular Weight 114379 DA
Gene ID 3996
UniProt Q15334
Research Area Cancer, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Katoh, Katoh: "Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico." in: International journal of oncology, Vol. 24, Issue 3, pp. 737-42, 2004 (PubMed).

Grifoni, Garoia, Schimanski et al.: "The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo." in: Oncogene, Vol. 23, Issue 53, pp. 8688-94, 2004 (PubMed).

Schimanski, Schmitz, Kashyap et al.: "Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer." in: Oncogene, Vol. 24, Issue 19, pp. 3100-9, 2005 (PubMed).

Alternatives for antigen "Lethal Giant Larvae Homolog 1 (Drosophila) (LLGL1)", type "Antibodies"
Hosts (18), (3)
Reactivities (21), (12), (12), (12), (12)
Applications (12), (10), (9), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (1), (1)
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