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Peptidyl Arginine Deiminase, Type IV (PADI4) (AA 512-544), (C-Term) antibody

Details for Product No. ABIN389125, Supplier: Log in to see
Antigen
  • PAD
  • PAD4
  • PADI5
  • PDI4
  • PDI5
  • Pad4
  • Pdi4
Epitope
AA 512-544, C-Term
15
13
4
4
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
92
9
7
1
1
1
1
1
1
1
Host
Rabbit
55
21
15
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
70
28
21
19
12
11
6
5
4
4
2
2
2
1
1
1
1
Supplier
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Immunogen This PAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 512-544 AA from the C-terminal region of human PAD4.
Clone RB07589
Isotype Ig
Specificity This PAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PAD4.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name PAD4 (PADI4 Antibody Abstract)
Background PAD4 is a member of a family of enzymes responsible for the conversion of arginine residues to citrulline residues via catalyzation of the deimination of the arginine residues. PAD4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response.
Synonyms: Protein-arginine deiminase type IV, Peptidylarginine deiminase IV, HL-60 PAD, PADI4, PADI5, PDI5,
Molecular Weight 74095 DA
Gene ID 23569
UniProt Q9UM07
Research Area Signaling, Protein Modifications, Cancer, Chromatin, Cell Structure
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (AA 512-544), (C-Term) antibody (ABIN389125) Western blot analysis of anti-PAD4 Pab (ABIN389125) in 293 cell line lysate. PAD4(arr...
Background publications Nakayama-Hamada, Suzuki, Kubota et al.: "Comparison of enzymatic properties between hPADI2 and hPADI4." in: Biochemical and biophysical research communications, Vol. 327, Issue 1, pp. 192-200, 2005 (PubMed).

Wang, Wysocka, Sayegh et al.: "Human PAD4 regulates histone arginine methylation levels via demethylimination." in: Science (New York, N.Y.), Vol. 306, Issue 5694, pp. 279-83, 2004 (PubMed).

Arita, Hashimoto, Shimizu et al.: "Structural basis for Ca(2+)-induced activation of human PAD4." in: Nature structural & molecular biology, Vol. 11, Issue 8, pp. 777-83, 2004 (PubMed).

Barton, Bowes, Eyre et al.: "A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population." in: Arthritis and rheumatism, Vol. 50, Issue 4, pp. 1117-21, 2004 (PubMed).

Suzuki, Yamada, Chang et al.: "Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. ..." in: Nature genetics, Vol. 34, Issue 4, pp. 395-402, 2003 (PubMed).