Peptidyl Arginine Deiminase, Type IV (PADI4) (C-Term), (AA 512-544) antibody

Details for Product No. ABIN389125
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Antigen
Synonyms PAD, PAD4, PDI4, PDI5, PADI5, Pad4, Pdi4
Epitope
C-Term, AA 512-544
(13), (4), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(60), (7), (7), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(45), (11), (5)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(51), (26), (16), (13), (10), (8), (7), (5), (3), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN389125
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This PAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 512-544 AA from the C-terminal region of human PAD4.
Clone RB07589
Isotype Ig
Specificity This PAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PAD4.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name PAD4
Background PAD4 is a member of a family of enzymes responsible for the conversion of arginine residues to citrulline residues via catalyzation of the deimination of the arginine residues. PAD4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response.
Synonyms: Protein-arginine deiminase type IV, Peptidylarginine deiminase IV, HL-60 PAD, PADI4, PADI5, PDI5,
Molecular Weight 74095 DA
Gene ID 23569
UniProt Q9UM07
Research Area Signaling, Protein Modifications, Cancer, Chromatin, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (C-Term), (AA 512-544) antibody Western blot analysis of anti-PAD4 Pab (ABIN389125) in 293 cell line lysate. PAD4(arrow) was detected using the purified polyclonal antibody.
Background publications Suzuki, Yamada, Chang et al.: "Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis." in: Nature genetics, Vol. 34, Issue 4, pp. 395-402, 2003 (PubMed).

Barton, Bowes, Eyre et al.: "A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population." in: Arthritis and rheumatism, Vol. 50, Issue 4, pp. 1117-21, 2004 (PubMed).

Arita, Hashimoto, Shimizu et al.: "Structural basis for Ca(2+)-induced activation of human PAD4." in: Nature structural & molecular biology, Vol. 11, Issue 8, pp. 777-83, 2004 (PubMed).

Wang, Wysocka, Sayegh et al.: "Human PAD4 regulates histone arginine methylation levels via demethylimination." in: Science (New York, N.Y.), Vol. 306, Issue 5694, pp. 279-83, 2004 (PubMed).

Nakayama-Hamada, Suzuki, Kubota et al.: "Comparison of enzymatic properties between hPADI2 and hPADI4." in: Biochemical and biophysical research communications, Vol. 327, Issue 1, pp. 192-200, 2005 (PubMed).

Hosts (45), (11), (5)
Reactivities (60), (7), (7), (1), (1), (1), (1), (1), (1)
Applications (51), (26), (16), (13), (10), (8), (7), (5), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (4), (2), (2), (1), (1), (1), (1), (1)
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