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Details for Product No. ABIN389125

Peptidyl Arginine Deiminase, Type IV (PADI4) (C-Term), (AA 512-544) antibody

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Antigen
Synonyms PAD, PAD4, PDI4, PDI5, PADI5, Pad4, Pdi4
Epitope
»Alternatives C-Term, AA 512-544
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN389125
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (C-Term), (AA 512-544) antibody

Product details

Target Details Application Details Handling Images References Alternatives back to top
Immunogen This PAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 512-544 AA from the C-terminal region of human PAD4.
Clone RB07589
Isotype Ig
Specificity This PAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PAD4.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Target Details

Application Details Handling Images References Alternatives back to top
Alternative Name PAD4
Background PAD4 is a member of a family of enzymes responsible for the conversion of arginine residues to citrulline residues via catalyzation of the deimination of the arginine residues. PAD4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response.
Synonyms: Protein-arginine deiminase type IV, Peptidylarginine deiminase IV, HL-60 PAD, PADI4, PADI5, PDI5,
Molecular Weight 74095 DA
Gene ID 23569
UniProt Q9UM07
Research Area Signaling, Protein Modifications, Cancer, Chromatin, Cell Structure

Application Details

Target Details Handling Images References Alternatives back to top
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only

Handling

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Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months

References

Target Details Application Details Handling Images Alternatives back to top
Background publications Suzuki, Yamada, Chang et al.: "Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis." in: Nature genetics, Vol. 34, Issue 4, pp. 395-402, 2003 (PubMed).

Barton, Bowes, Eyre et al.: "A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population." in: Arthritis and rheumatism, Vol. 50, Issue 4, pp. 1117-21, 2004 (PubMed).

Arita, Hashimoto, Shimizu et al.: "Structural basis for Ca(2+)-induced activation of human PAD4." in: Nature structural & molecular biology, Vol. 11, Issue 8, pp. 777-83, 2004 (PubMed).

Wang, Wysocka, Sayegh et al.: "Human PAD4 regulates histone arginine methylation levels via demethylimination." in: Science (New York, N.Y.), Vol. 306, Issue 5694, pp. 279-83, 2004 (PubMed).

Nakayama-Hamada, Suzuki, Kubota et al.: "Comparison of enzymatic properties between hPADI2 and hPADI4." in: Biochemical and biophysical research communications, Vol. 327, Issue 1, pp. 192-200, 2005 (PubMed).

Alternatives

Target Details Application Details Handling Images References back to top
Alternatives for antigen "Peptidyl Arginine Deiminase, Type IV (PADI4)", type "Antibodies"
Hosts (43), (10), (6)
Reactivities (58), (6), (5), (1), (1), (1), (1), (1), (1)
Applications (49), (26), (12), (11), (10), (6), (6), (5), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (5), (4), (2), (2), (1), (1), (1), (1)
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